Innate Immun：CD40上调树突状细胞与Th17/Treg失衡从而促进年轻人慢性牙周炎的骨丧失

2020-10-03 MedSci原创 MedSci原创

本研究旨在发现年龄对慢性牙周炎发病的影响，并探究这一过程中的分子机制，研究结果已在线发表于Innate Immun。

本研究旨在发现年龄对慢性牙周炎发病的影响，并探究这一过程中的分子机制，研究结果已在线发表于Innate Immun。

研究采集了63名慢性牙周炎患者和30名健康对照组的血液样本。使用流式细胞仪分析Th17细胞/foxp3+调节性T细胞(Treg)比例和树突状细胞(DCs)中共刺激分子的表达。通过ELISA检测血清中可溶性CD40配体（CD40L）和IL-17的水平。

结果显示，年轻的慢性牙周炎患者中，Th17/Treg比值明显高于老年患者。年轻慢性牙周炎患者DC上的CD40、CD40L和IL-17的血清水平均较高。成熟DCs的CD40表达水平高，可使Th17/Treg比值在体外升高。

综上所述，该研究结果表明，在慢性牙周炎的发病过程中，年轻患者的Th17/Treg比值高于老年患者，这一现象与DCs中CD40的表达水平不同是一致的。

原始出处：

Xin Su, Jiahui Zhang, Xue Qin. CD40 up-regulation on dendritic cells correlates with Th17/Treg imbalance in chronic periodontitis in young population. Innate Immun. 2020 Aug;26(6):482-489. doi: 10.1177/1753425920917731.

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2020-12-14 liye789132251

#Nat#

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2021-04-11 qidongfanjian

#CD4#

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2021-02-06 mei543

#骨丧失#

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2020-10-04 piaojinhua

#慢性牙周炎#

41 0
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2020-10-04 zhaojie88

#Th17#

50 0
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2020-10-04 医者仁心

#牙周#

38 0
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2020-10-04 12498484m48(暂无昵称)

#Treg#

36 0

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