Pediatrics:极早产儿在学龄期易发生认知功能损害

2016-05-30 phylis 译 MedSci原创

背景:尽管极早产儿的死亡率和发病率有所降低,他们发生神经认知功能缺陷的风险较高,高达40%的孩子在学龄期有明显的认知功能障碍。研究者应用当代美国873个10岁孩子的队列,评估其神经认知功能损害率,这些孩子在孕28周内出生。方法:2002年到2004年,在5个州的14个地区招募889个家庭中的966个(92%)孩子,在孩子10岁时,进行IQ,语言,注意力,执行功能,处理速度,视觉感知,视觉运动功能,

背景:尽管极早产儿的死亡率和发病率有所降低,他们发生神经认知功能缺陷的风险较高,高达40%的孩子在学龄期有明显的认知功能障碍。研究者应用当代美国873个10岁孩子的队列,评估其神经认知功能损害率,这些孩子在孕28周内出生。

方法:2002年到2004年,在5个州的14个地区招募889个家庭中的966个(92%)孩子,在孩子10岁时,进行IQ、语言、注意力、执行功能、处理速度、视觉感知、视觉运动功能、学术成就的综合评估。

结果:总共有873名儿童进行了良好效度的认知和学术成就的综合评估。测试成绩的分布是一致的,并且显著低于常模。三分之一到三分之二的儿童低于相同年龄值的一个SD。执行功能和处理速度是下降最多的。校正社会经济地位,生长受限及其他潜在的混杂因素后,多变量分析发现在在所有18项检测中,最低胎龄不良预后的风险是最高的。

结论:队列中超过一半以上的极早产儿在10岁时,出现中度或严重的神经认知功能障碍,在那些最低胎龄的孩子,损害越严重。极早产儿神经认知功能和学术成绩持续损害的风险较高,在幼儿期应强调监测和修复这些不良结果。

原始出处:

Joseph RM, O'Shea TM, et al. Neurocognitive and Academic Outcomes at Age 10 Years of Extremely Preterm Newborns. Pediatrics. 2016 Mar 22.


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    2017-02-28 hbwxf
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    2016-06-07 feather89
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    2016-06-15 早茶月光

    之前一篇文献说过期儿有利于认知功能但有其他风险。。。看来还是足月儿比较安全

    0

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    2016-05-31 足球疯子

    不容易,小宝贝

    0

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