Eur Respir J:鉴别儿童严重哮喘新工具:吸入性糖皮质激素依从性电子监测

2018-01-19 闫盈盈 环球医学

发表于《Eur Respir J》上的一篇研究,提出吸入性糖皮质激素依从性的电子监测是鉴别儿童严重哮喘的一种必不可少的工具。

发表于《Eur Respir J》上的一篇研究,提出吸入性糖皮质激素依从性的电子监测是鉴别儿童严重哮喘的一种必不可少的工具。

国际指南推荐,严重哮喘仅可在解决了促成因素后确诊,包括依从性。临床实践中,准确评估依从性非常困难。研究者假设,对儿童进行电子监测可识别出非依从性,因此可以确定小数量的真正严重哮喘患者。研究者前瞻性招募了已经开具了吸入性糖皮质激素处方的哮喘儿童,并使用电子监测设备评估依从性的持续性。研究者在监测开始和结束时监测了肺活量、气道炎症和哮喘控制。共监测了93名儿童(62名男性,中位12.4岁),中位监测时间为92天。中位(范围)监测的依从率为74%(21~99)。研究者鉴别出4组:(1)监测期间依从性良好且控制改善,24%(之前可能依从性较差);(2)依从性良好但控制较差,18%(严重难治性哮喘);(3)依从性较差但控制良好,26%(可能过度治疗);(4)依从性较差且控制较差,32%。监测前没有临床参数可以区分这些组。电子监测是一种有用的工具,可以用来识别显现出的需要加强治疗的儿童。无论是否依从,疾病都得到控制的患者,需要不同的检测方法。电子监测在儿童严重哮喘门诊中是必要的。

原始出处:
Jochmann A, Artusio L, Jamalzadeh A, et al.Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children.Eur Respir J. 2017 Dec 21;50(6). pii: 1700910. doi: 10.1183/13993003.00910-2017. Print 2017 Dec.

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    2018-01-21 fyxzlh
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    2018-01-19 139****0239

    henhao

    0

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