JCO:Oncotype DX乳腺癌检测的种族差异

2015-12-02 zhaozhou译 MedSci原创

 安可待(Oncotype DX,ODX)是一种进行肿瘤基因表达检测的工具。ODX对于辅助化疗的决策制定有着辅助作用。ODX有提升改善监护质量的潜能。但是对于不同种族人群来说,仍然存在癌症监护质量的差异,甚至变得更为恶化。 研究人员收集了卡罗来纳乳腺癌研究(Carolina Breast Cancer Study,这是临床三期、纵向的、基于人群的研究,在2008年至2014年间

安可待(Oncotype DX,ODX)是一种进行肿瘤基因表达检测的工具。ODX对于辅助化疗的决策制定有着辅助作用。ODX有提升改善监护质量的潜能。但是对于不同种族人群来说,仍然存在癌症监护质量的差异。


研究人员收集了卡罗来纳乳腺癌研究(Carolina Breast Cancer Study,这是临床III期、纵向的、基于人群的研究,在2008年至2014年间接受乳腺癌诊断的北卡罗来纳州2998名妇女参与其中)。研究人员使用校正的泊松回归进行分析来确定种族和ODX检测是否在淋巴结阴性和阳性乳腺癌患者中的使用存在差异。共有1468名雌激素受体阳性、人表皮生长因子受体2阴性、I期或II期乳腺癌女性患者符合了研究的条件。黑人患者有着更严重和更大的肿瘤,更多的并发症,并且被诊断为乳腺癌的年龄更小,而且相对于非黑人女性,黑人女性患者的社会经济地位更低。总体来说,有42%的女性在她们的病理报告中有ODX检测结果。相对于没有接受ODX检测的患者,接受了ODX检测的女性更加年轻,肿瘤大小属于中等。淋巴结阳性患者中,黑人患者比其他患者有着低46%的可能性接受ODX检测。

此项研究表明,对于淋巴结阴性患者,ODX检测并无种族差异。但是,黑人女性更少接受用于淋巴结阳性乳腺癌检测的ODX检测。

原始出处:

Megan C. Roberts, Morris Weinberger,etal. Racial Variation in the Uptake of Oncotype DX Testing for Early-Stage Breast Cancer. JOURNAL OF CLINICAL ONCOLOGY. November 23, 2015 

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    2016-09-08 lidong40
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    2016-02-24 feather89
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    2015-12-04 老段

    有种族差异

    0

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