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Diabetes Care：沙格列汀新用户急性心肌梗死风险如何？

2017-11-10 xing.T MedSci原创

沙格列汀急性心肌梗死风险
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在美国食品和药物管理局批准沙格列汀使用后的头5年，研究人员没有发现沙格列汀使用者的AMI风险高于其他选定的降血糖药使用者。

与其他降糖治疗相比，二肽基肽酶4抑制剂沙格列汀的心血管安全性尚不清楚。近日，糖尿病领域权威杂志Diabetes Care上发表了研究文章，研究人员前瞻性地探究了沙格列汀的使用与急性心肌梗死（AMI）之间的关系。

研究人员使用18个小型监测合作伙伴的数据，确定了从2009年开始服用沙格列汀治疗到2014年8月并且年龄≥18岁的患者。研究人员使用疾病风险评分（DRS）分层和倾向评分（PS），调整潜在的混杂因素后，进行了七项连续评估后，比较了沙格列汀分别与西他列汀、吡格列酮、第二代磺脲类药物和长效胰岛素的效果。每个成对比较时连续检验保持的假阳性信号低于0.05（单侧）。

研究人员确定了82264名沙格列汀使用者。在监测结束时，与西格列汀比较，DRS分层的风险比（HRs）（95％CI）分别为1.08（0.90-1.28），与吡格列酮相比为1.11（0.87-1.42），与磺脲类药物相比为0.79（0.64-0.98），与长效胰岛素相比为0.57（0.46-0.70）。相应PS匹配的HR类似。只有一个对168项分析符合安全性信号标准的中期分析：从第五次连续分析的PS匹配的沙格列汀-吡格列酮比较，得出HR为1.63（1.12-2.37），这种联系在随后的分析中消失。

在美国食品和药物管理局批准沙格列汀使用后的头5年，研究人员没有发现沙格列汀使用者的AMI风险高于其他选定的降血糖药使用者。

原始出处：

Sengwee Toh, et al. Prospective Postmarketing Surveillance of Acute Myocardial Infarction in New Users of Saxagliptin: A Population-Based Study.Diabetes Care 2017. https://doi.org/10.2337/dc17-0476

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    2018-06-25 ms9608593228839890

    #DIA#

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    2017-11-21 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  4. 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    2017-11-21 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  5. 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    2017-11-21 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  6. 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createdName=lou.minghong, createdTime=Sat Nov 11 01:30:14 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260323, encodeId=74b726032383, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Nov 10 18:48:08 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2018-02-09 木头人513

    #Diabetes#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=260468, encodeId=7ed62604689c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4cyIbibqa2VuNGCKeyRxITYNqLTIaoFo3Jx2LSawp8yrFSs1CIXKv1jyXV97ecnxhhktGKkPP9onfJFZCbiayLgic/0, createdBy=3f1c1956638, createdName=1e127dd4m40(暂无匿称), createdTime=Sat Nov 11 08:47:18 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260387, encodeId=27ab26038e12, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sat Nov 11 01:30:14 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260323, encodeId=74b726032383, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Nov 10 18:48:08 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-12 pyaili

    #沙格列汀#

    0

  8. 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    2017-11-11 1e127dd4m40(暂无匿称)

    学习了

    0

  9. 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    2017-11-11 lou.minghong

    学习了谢谢分享!

    0

  10. 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    2017-11-10 惠映实验室

    学习了.谢谢.

    0

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