当代版“返老还童”!吸高压氧90天,65岁皮肤年轻20%

2022-08-11 木子久 生物探索

从古至今,人们都没有放弃对“永生的追求”,古有各代帝王为延寿寻医问药,今有富豪为抗衰一掷千金,也正因如此,延寿、抗衰正在逐渐成为科学家们追求的崭新领域。

2018年,耶鲁大学研究人员成功复活已死去猪的大脑,使其存活期延长了36小时;2022年5月,葡萄牙科学家发现了新的延寿“开关”——FOXM1,通过这一基因可使自然衰老小鼠的寿命延长28%;2022年8月,来自耶鲁大学的研究人员再次实现新突破,通过外接设备在猪死后恢复了其部分器官功能;而今来自以色列特拉维夫大学的研究人员发现,通过高压氧技术可使65岁老年人的皮肤年轻20%

这项研究以“Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial”为题,发表在国际权威期刊Aging上。通过科学实验,来自以色列特拉维夫大学的科研人员发现,在高压氧技术的辅助下,每周吸氧长达450分钟之后,多位65岁的老年志愿者其皮肤老化细胞减少了约20%左右,就连象征老年标志物的老年斑也得到了显著改善[1]。

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1 研究成果(图源:[1]

在这项研究中,研究人员共计招募了35名年龄在64岁及以上的老年人志愿者,使这些志愿者们每天接受60次高压氧疗法(Hyperbaric oxygen therapy,HBOT),每周5天,每次持续时间为90分钟,每20分钟给予5分钟的高氧中断,模仿高氧环境下的缺氧变化,让缺氧诱发机体代谢变化。在基线时、第30次HBOT后以及第60次HBOT后采集老年人志愿者的血样样本,随后对其外周血单个核细胞的端粒长度以及衰老程度进行评估。

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2 端粒长度随HBOT的变化(图源:[1]

 

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3 HBOT治疗导致的志愿者体内衰老细胞数量的变化(图源:[1]

研究发现:

■ 与基线相比,在半程、全程和HBOT治疗后,T辅助细胞的端粒长度分别显著增加21.7%、23.69%、29.3%;B细胞端粒长度增加25.68%、29.39%和37.63%;自然杀伤细胞端粒长度在半程和全程时增加20.56%,在HBOT治疗后增加22.16%;细胞毒性T细胞在半程、全程和HBOT治疗后分别增加18.29、24.13%、19.59%。

■ 在实验半程和全程时,衰老的T辅助细胞数量分别减少了19.66%和11.67%,在HBOT治疗后,衰老T辅助细胞数量显著下降了37.3%;衰老细胞毒性T细胞数量在实验半程、全程和完全治疗后分别下降12.21%、9.81%、10.96%。

总而言之,通过这项研究,科研人员发现,每天重复HBOT治疗可以使老年人群体内细胞端粒长度增加20%以上,其中B细胞的变化最显著。此外,HBOT治疗还可以使老年人体内衰老细胞数量显著减少,其中T辅助细胞的衰老细胞受影响最大

近年来,为了延寿和抗衰,科研人员在这条科研路上不遗余力地探索着。不管是高压氧技术,还是其他抗衰延寿方法,都仅仅只是人们追求“永生”的千万条路径之一。硅谷创投大佬彼得希尔每季度花费4万美元用以换取“年轻血液”,以保持机体活力;奇点大学校长库兹韦尔计划花费20万美元预定“人体冷冻术”……

其实,对于大多数普通人来说,我们在日常生活中能维持健康的生活方式就是延寿抗衰的最佳方式,比如良好的饮食习惯、勤于锻炼等等。

参考资料:

[1]Hachmo Y, Hadanny A, Abu Hamed R, et al. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY). 2020 Nov 18;12(22):22445-22456. doi: 10.18632/aging.202188. Epub 2020 Nov 18. PMID: 33206062; PMCID: PMC7746357.

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    2023-07-21 shirly.li19560809 来自浙江省

    有这么神奇的效果,赶紧去试试吧

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2149166, encodeId=3baa214916613, content=有这么神奇的效果,赶紧去试试吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f72b1400629, createdName=shirly.li19560809, createdTime=Fri Jul 21 15:42:58 CST 2023, time=2023-07-21, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=1238476, encodeId=dd5b12384e673, content=反过来说,缺氧肯定不了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sat Aug 13 15:38:44 CST 2022, time=2022-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361648, encodeId=028413616481d, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Fri Aug 12 01:07:39 CST 2022, time=2022-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401596, encodeId=71c114015966d, content=<a href='/topic/show?id=e3681022810d' target=_blank style='color:#2F92EE;'>#高压氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102281, encryptionId=e3681022810d, topicName=高压氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52152357213, createdName=陈吴1235, createdTime=Fri Aug 12 01:07:39 CST 2022, time=2022-08-12, status=1, ipAttribution=)]
    2022-08-13 carrotlyl

    反过来说,缺氧肯定不了

    0

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