Jaguar的Crofelemer很可能作为一种非抗生素类,治疗肠易激综合症相关腹部疼痛的新选择

2020-01-09 不详 MedSci原创

Jaguar Health公司公布其crofelemer治疗腹泻为主的肠易激综合症(IBS-D)相关腹痛的临床2期研究结果。

Jaguar Health公司公布其crofelemer治疗腹泻为主的肠易激综合症(IBS-D)相关腹痛的临床2期研究结果。

这项多中心,2期,随机,双盲,安慰剂对照试验评估了crofelemer对IBS-D女性腹痛的影响。共有240名女性入选,参与者随机分配每天两次服用crofelemer(125 mg)或安慰剂。

研究结果分析显示,Crofelemer组在第1个月至第2个月(58.3%对45.0%,与安慰剂相比,P = 0.030)以及整个3个月(54.2%对42.5%,P = 0.037)应答患者的比例明显更高。并且每月应答者大便稠度的比例没有观察到显着差异。

这些趋势表明,Crofelemer可用于治疗IBS-D患者的腹痛,而对排便没有显着改变。目前,很少有治疗方法可以解决与IBS-D相关的内脏疼痛。Crofelemer具有独特而新颖的抗分泌作用,可调节囊性纤维化跨膜电导调节剂(CFTR)/钙激活的氯离子通道(CaCC),提供一种新的非抗生素类治疗IBS-D患者的内脏疼痛和不适的方法。

IBS是最常见的肠道疾病,在北美的人口患病率高达12%,女性比男性更普遍。

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