AIDS:依洛尤单抗对HIV和血脂异常患者的长期影响

2022-01-18 “心关注”公众号 “心关注”公众号

近日,一项发表在AIDS杂志上的研究显示,

近日,一项发表在AIDS杂志上的研究显示,长期服用依洛尤单抗可降低LDL-C和非HDL-C水平,并有助于更多的艾滋病病毒携带者达到推荐的脂质管理目标而没有严重的不良事件反应

艾滋病病毒携带者患动脉粥样硬化性心血管疾病的风险呈增加趋势,而这类人群对他汀类药物的欠佳反应可能源于某些抗逆转录病毒治疗(ART)。为评估依洛尤单抗在艾滋病病毒携带者中的安全性和有效性,研究者开展了一项跨国、安慰剂对照、双盲、随机、3期临床试验,分析在开放标签(OLP)期间,每月皮下注射依洛尤单抗 420 mg对伴有高胆固醇血症/混合型血脂异常的艾滋病病毒携带者24周后LDL-C水平的影响,并统计紧急不良事件(TEAEs)。

研究结果显示,在双盲随机分配的467例参与者中,451例(96.6%)在OLP期间接受了至少一剂的依洛尤单抗治疗(平均年龄56.4岁,82.5%为男性,平均感染HIV的时间为17.4年)。到52周OLP结束时,LDL-C的总体平均百分比变化为-57.8%(22.8%)。依洛尤单抗还降低了甘油三酯、致动脉粥样硬化的相关脂质参数(非HDL-C、载脂蛋白B、总胆固醇、极低密度脂蛋白胆固醇和脂蛋白[a]),并增加了HDL-C水平。在OLP期间,安慰剂和依洛尤单抗的TEAEs相似。

原始出处:

Boccara F, Caramelli B, Calmy A, Kumar P, et al. Long-term effects of evolocumab in participants with HIV and dyslipidemia: results from the open-label extension period. AIDS. 2022 Jan 12. doi: 10.1097/QAD.0000000000003175. Epub ahead of print. PMID: 35025817.

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    2022-04-02 wjywjy
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    2022-01-20 cooco
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    2022-01-18 ms4000001513304915

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