Endocr Pract:原发性甲状旁腺功能亢进症患者的维生素D研究

2016-10-05 Mechront 译 MedSci原创

研究数据显示,健康成人和原发性甲状旁腺功能亢进成年患者,其自由和生物有效性25羟维生素D水平是相似的。 不过,原发性甲状旁腺功能亢进症成年患者的血清25(OH)D水平更低。 来自罗伯特木材约翰逊医学院的Xiangbing Wang博士称:较低的25(OH)D水平可能反映不出原发性甲状旁腺功能亢进症患者的真正维生素D状态。 Wang和他的同事评估了50名原发性甲状旁腺功能亢进症成年

研究数据显示,健康成人和原发性甲状旁腺功能亢进成年患者,其自由和生物有效性25羟维生素D水平是相似的。

不过,原发性甲状旁腺功能亢进症成年患者的血清25(OH)D水平更低。

来自罗伯特木材约翰逊医学院的Xiangbing Wang博士称:较低的25(OH)D水平可能反映不出原发性甲状旁腺功能亢进症患者的真正维生素D状态。

Wang和他的同事评估了50名原发性甲状旁腺功能亢进症成年患者(平均年龄58.3岁)和50名年龄、性别和体重指数相匹配的对照组(平均年龄58岁),探究自由和生物有效性25(OH)D水平的组间差异。

总的来说,36%的原发性甲状旁腺功能亢进症患者,其25(OH)D水平低于20 ng/mL。与对照组相比,原发性甲状旁腺功能亢进症患者的总25(OH)D水平和维生素D结合蛋白水平更低(P < .01)。

两组参与者有相似的白蛋白结合25(OH)D水平;但是对照组维生素D结合蛋白25-(OH)D水平更高(P < .01)。原发性甲状旁腺功能亢进症患者的白蛋白水平低于对照组(P < .05)。

研究者发现,血清维生素D结合蛋白水平和甲状旁腺激素、钙水平之间呈负相关(P < .01);血清维生素D结合蛋白水平与25-(OH)D(P < .05)和白蛋白水平(P < .05)水平之间呈正相关。

研究者称:我们的研究结果表明,总25(OH)D水平可能不能够准确的反应原发性甲状旁腺功能亢进症患者的生物有效性25羟维生素D水平。临床医生应该意识到,原发性甲状旁腺功能亢进症患者出现低水平25-(OH)D,可能存在高钙血症恶化。未来需要进一步调查维生素D结合蛋白、25-(OH)D和原发性甲状旁腺功能亢进症病因之间的联系。

原始出处:

Total serum 25-(OH)D levels lower in primary hyperparathyroidism vs. healthy adults.Helaio.October 4, 2016

Wang X, et al. FREE AND BIOAVAILABLE 25-HYDROXYVITAMIN D LEVELS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM.Endocr Pract. 2016;doi:10.4158/EP161434.OR.

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1846513, encodeId=975f1846513c5, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Tue Mar 14 04:43:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379538, encodeId=aeb013e9538a3, content=<a href='/topic/show?id=82e369829c0' target=_blank style='color:#2F92EE;'>#甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69829, encryptionId=82e369829c0, topicName=甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b796455, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 10:07:11 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140811, encodeId=c58614081148, content=學習啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 10:06:59 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140663, encodeId=4b3d140663fd, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, 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  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:31 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-06 医路开来

    謝謝分享,,,

    0

  6. 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topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Fri Oct 07 11:43:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140813, encodeId=81f714081355, content=謝謝分享,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 10:07:17 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140812, encodeId=e17814081208, content=很不錯的文章,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:31 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-06 医路开来

    很不錯的文章,,

    0

  7. 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topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Fri Oct 07 11:43:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140813, encodeId=81f714081355, content=謝謝分享,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 10:07:17 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140812, encodeId=e17814081208, content=很不錯的文章,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 10:07:11 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140811, encodeId=c58614081148, content=學習啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 10:06:59 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140663, encodeId=4b3d140663fd, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:31 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-06 医路开来

    學習啦,,,

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:31 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 知难而进

    继续关注!

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:31 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 知难而进

    谢谢分享!

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:58 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140662, encodeId=df0c14066296, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:51 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140661, encodeId=79a5140661e7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Oct 05 22:40:31 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 知难而进

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