Z Gerontol Geriatr:α-硫辛酸或可抵消饮酒对骨质量和骨强度的负影响

2019-10-13 不详 网络

既往研究表明,饮酒(ALH)对骨骼组织和骨骼代谢具有破坏作用。α-硫辛酸(ALA)可促进成骨细胞增殖并抑制破骨细胞增殖,正向影响骨骼再生;但是,有关ALA摄入对老年雌性大鼠ALA骨丧失的影响尚未明了。本研究旨在调查ALA治疗对老年ALH摄入对雌性大鼠骨丧失的影响。在这项研究中,纳入了30只雌性Sprague-Dawley大鼠(22个月大),重约520微克。将动物随机分为三组:CON组,ALH组和A

既往研究表明,饮酒(ALH)对骨骼组织和骨骼代谢具有破坏作用。α-硫辛酸(ALA)可促进成骨细胞增殖并抑制破骨细胞增殖,正向影响骨骼再生;但是,有关ALA摄入对老年雌性大鼠ALA骨丧失的影响尚未明了。本研究旨在调查ALA治疗对老年ALH摄入对雌性大鼠骨丧失的影响。

在这项研究中,纳入了30只雌性Sprague-Dawley大鼠(22个月大),重约520微克。将动物随机分为三组:CON组,ALH组和ALH + + ALA组,分别接受盐水,ALH,ALH加ALA治疗直至16周死亡。通过组织学,微计算机断层扫描,基因表达分析和生物力学测试,评估了摄入ALH的老年雌性大鼠维持骨质量和骨强度的结果。

结果显示,ALH + + ALA可以有效预防和治疗老年ALH雌性大鼠骨质疏松症。ALH + ALA对骨体积比(BV / TV),小梁厚度(Tb.Th),小梁数目(Tb.N)和小梁分离度(Tb.Sp),BMD和股骨远端强度产生更大的影响,并且调节成骨和骨吸收相关基因的表达。

总之,这些结果似乎表明,ALA干预可预防摄入ALH的老年雌性大鼠的骨丧失。

原始出处:

Zhan J, Jiang Y, et al., Administration of alpha-lipoic acid could maintain bone mass and bone strength in senile female rats with alcohol consumption. Z Gerontol Geriatr. 2019 Oct 10. doi: 10.1007/s00391-019-01630-3.

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