Nat Commun:研究发现miR-31是调节乳腺癌干细胞活性及肿瘤发生的关键因子

2017-11-02 MedSci MedSci原创

微小RNA介导的转录后调控在干细胞自我更新和肿瘤发生中起关键作用。然而,特异性微小RNA在控制乳腺干细胞(MaSC)活性和乳腺癌形成中的体内功能仍然知之甚少。本研究中,研究人员发现,在富含MaSC的乳腺基底细胞群体和乳腺肿瘤中miR-31高度表达,并受NF-κB信号传导的调节。研究结果证明miR-31在体内分化以促进乳腺上皮增殖和MaSC的扩增。miR-31的缺失可影响乳腺肿瘤生长,减少癌细胞的数

微小RNA介导的转录后调控在干细胞自我更新和肿瘤发生中起关键作用。然而,特异性微小RNA在控制乳腺干细胞(MaSC)活性和乳腺癌形成中的体内功能仍然知之甚少。

本研究中,研究人员发现,在富含MaSC的乳腺基底细胞群体和乳腺肿瘤中miR-31高度表达,并受NF-κB信号传导的调节。研究结果证明miR-31在体内分化以促进乳腺上皮增殖和MaSC的扩增。miR-31的缺失可影响乳腺肿瘤生长,减少癌细胞的数量,并降低肿瘤起始能力和肺转移,表明miR-31的致癌作用。

MiR-31调节多种信号通路,包括Prlr/Stat5、TGFβ和Wnt /β-连环蛋白。特别地,它通过直接靶向Wnt拮抗剂(包括Dkk1)来激活Wnt /β-连环蛋白信号传导。重要的是,Dkk1过表达部分逆转了miR-31诱导的乳腺缺陷。

综上所述,这些发现确定miR-31为MaSC活性和乳腺肿瘤发生的关键调节因子。

原始出处:


Cong Lv, Fengyin Li, Xiang Li, Yuhua Tian, et al., MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun. 2017; 8: 1036. Published online 2017 Oct 19. doi: 10.1038/s41467-017-01059-5

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    2018-08-19 liuli5079
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    2018-04-23 redcrab
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    2018-03-21 liye789132251
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    2018-01-23 smallant2002
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