Lancet Infect Dis:欧洲首批新冠肺炎患者临床特征研究

2020-03-30 MedSci原创 MedSci原创

研究人员详细阐述了5例SARS-CoV-2感染者的三种不同临床和生物学进展。研究人员相信,这些发现将有助于更好地了解该疾病进程,并将有助于在实施更有效的感染控制战略

2019年12月31日,中国湖北省武汉市报告了一组肺炎病例。致病菌是一种新型冠状病毒,命名为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。近日研究报告了欧洲首批确诊感染2019年冠状病毒病(COVID-19)病例的相关特征,该患者于2020年1月24日被确诊感染。
 
本病例分析中,包含5名患者,患者分别在Bichat-ClaudeBernard大学医院(法国巴黎)和Pellegrin大学医院(法国波尔多)治疗,经鼻咽拭子采样,RT-PCR诊断为COVID-19。 研究人员评估了不同样本(鼻咽和血液、尿液和粪便样本)的临床疾病和病毒载量。
 
病例包含3名男性(31岁、48岁和80岁)和2名女性(30岁和46岁),均来自中国,于2020年1月中旬从中国前往法国。患者出现不同的临床进展:(1)2名无症状的妇女在出现症状一天内被确诊,在确诊前24小时,患者鼻咽存在高滴度的SARS-CoV-2(分别为每1000个细胞5.2和7.4 log10个拷贝),在粪便中可检测到病毒RNA;(2)2名年轻男子存在2个阶段疾病进展,首先患者鼻咽样本病毒载量下降,但在疾病发生后10天左右继续恶化;(3)1名80岁男性,病情发展迅速,出现多器官衰竭,上、下呼吸道的病毒载量持续偏高,全身病毒散播及血浆病毒测试结果显示病毒载量持续偏高。这位80岁的病人于确诊后的第14天(2020年2月14日)死亡,其他病人均在2020年2月19日前康复并出院。
 
研究人员详细阐述了5例SARS-CoV-2感染者的三种不同临床和生物学进展。研究人员相信,这些发现将有助于更好地了解该疾病进程,并将有助于在实施更有效的感染控制战略。
 
原始出处:
 
Prof Francois-Xavier Lescure et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series.Lancet Infect Dis. March 27,2020.
 

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    2020-11-15 howi
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    2020-03-30 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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