Psych Med:常见抗抑郁药或可增加患冠状动脉粥样硬化的风险

2015-04-08 佚名 生物谷

近日,一项来自美国威克森林浸信医学中心(Wake Forest Baptist Medical Center)的研究成果表明,一种常见的抗抑郁药物或可使得非人灵长类动物冠状动脉粥样硬化斑块增加6倍,相关研究发表于国际杂志Psychosomatic Medicine上;冠状动脉粥样硬化(Coronary Artery Atherosclerosis, CAA)是引发心脏病的主要原因。Carol Sh

近日,一项来自美国威克森林浸信医学中心(Wake Forest Baptist Medical Center)的研究成果表明,一种常见的抗抑郁药物或可使得非人灵长类动物冠状动脉粥样硬化斑块增加6倍,相关研究发表于国际杂志Psychosomatic Medicine上;冠状动脉粥样硬化(Coronary Artery Atherosclerosis, CAA)是引发心脏病的主要原因。

Carol Shively教授说道,很多年以来医学团体都知道抑郁症和心脏疾病存在着密不可分的关系,但我们并不知道如果治疗抑郁症或许就可以降低个体患心脏疾病的风险;这项研究中,研究者给予42只中年雌性猴子喂以低脂肪低胆固醇的西方样饮食,时间长达18个月;在预处理阶段,研究者对动物的抑郁行为进行记录。

选择雌性猴子进行实验是因为冠状动脉心脏病是在美国是引发女性死亡的主要原因,而且抑郁症在女性个体中的发病是男性的两倍;随后研究者将实验动物随机指定每天接受常见的抗抑郁药物左洛复(选择性5羟色胺再吸收抑制剂,SSRI)或安慰剂,服用时间长达18个月,实验动物服用的抗抑郁药物和病人的服用量相当。

结果显示,接受SSRI的动物机体冠状动脉中形成的脂肪沉滞性动脉硬化的程度是安慰剂组的三倍,在抑郁症的动物中,这种脂肪沉滞性动脉硬化的程度更为明显,几乎是安慰剂组动物的6倍。Shively说道,本文研究表明,抗抑郁药物的长期治疗或会促进非人灵长类动物冠状动脉粥样硬化的发生,而这对于患者或许具有明显的临床意义,因为美国大约四分之一的中年女性都在服用抗抑郁药物,而且大多数的药物都是SSRI。

最后研究者补充道,尽管当前还需要进行更多的研究来证明抗抑郁药物的不良影响,但临床医生们在开具抗抑郁药物时需要谨慎,此前研究表明锻炼和咨询或许和SSRIs一样来有效治疗个体的抑郁症。

原始出处:

Shively, Carol A. PhD; Register, Thomas C. PhD; Appt, Susan E. DVM; Clarkson, Thomas B. DVM.Effects of Long-Term Sertraline Treatment and Depression on Coronary Artery Atherosclerosis in Premenopausal Female Primates.Psychosomatic Medicine, March 30, 2015; doi: 10.1097/PSY.0000000000000163

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    2016-01-09 wetgdt
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    2015-04-11 x35042875

    必须要接受教育、认可理念

    0

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