Diabetes Care:1型糖尿病青少年患者酮症酸中毒的发生率逐年增加!

2021-07-24 Nebula MedSci原创

从2010年至2016年,确诊为1型糖尿病或接近1型糖尿病的个体的DKA发生率逐年增加

糖尿病酮症酸中毒(DKA)是一种严重的、可能危及生命的糖尿病并发症。DKA的特征是高血糖、酮症和酸中毒,这是由胰岛素缺乏和反调节激素水平升高引起的。

Increase in Prevalence of Diabetic Ketoacidosis at Diagnosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

根据既往报道,2002年至2010年,1型糖尿病青少年患者的DKA的发生率约稳定在30%。本研究旨在调查2010年至2016年20岁以下的1型糖尿病患者的DKA发生率的变化趋势,同时分析观察到的任何变化是否与新确诊的患者的社会人口分布变化有关。

DKA的发生率随时间的变化

研究人员按年份计算了7612例1型糖尿病患者(平均10.1岁)确诊后1个月内的DKA发生率,并评估其随时间推移的变化趋势。DKA的发生率从2010年的35.3%增加到了2016年的40.6%(p趋势=0.01)。

为了评估观察到的趋势是否归因于1型糖尿病青少年患者社会人口因素分布的变化,研究人员估算了根据年龄、性别、种族/民族、收入、教育、健康保险状况、语言、诊断季节和青年糖尿病研究网站的搜索校正后的DKA相对风险。根据社会人口因素调整后,DKA发生率随时间推移而增加的趋势未发生实质性改变。此外,研究人员观察到在1型糖尿病确诊或接近确诊时的DKA发生率每年增加2%(校正后的RR 1.02;p=0.01)。

综上所述,从2010年至2016年,确诊为1型糖尿病或接近1型糖尿病的个体的DKA发生率逐年增加;而且,这种增加似乎不是由于社会人口因素分布的变化造成的。

原始出处:

Elizabeth T. Jensen, et al. Increase in Prevalence of Diabetic Ketoacidosis at Diagnosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care 2021 Jul; 44(7): 1573-1578.

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  5. 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  6. 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  7. 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  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002344, encodeId=49cd10023447c, content=非常受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/725901dc0ed249ebba9d096aacddde3f/a89b874e17434adb82b0c2dff5f374f1.jpg, createdBy=c0225555986, createdName=@gxl, createdTime=Sat Jul 24 19:21:12 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-07-26 mashirong
  9. 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    2021-07-24 @gxl

    非常受用

    0

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