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JCEM：miR-181a-5p 和 miR-23a-3p表达变化与肥胖及胰岛素抵抗有关

2018-02-09 MedSci MedSci原创

miR-181a-5pmiR-23a-3p胰岛素抵抗
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大家都知道促炎细胞因子TNFα是胰岛素抵抗（IR）的关键因素。虽然一些miRNA被认为与脂肪组织（AT）IR的发展有关，但是miRNA在炎症与IR之间的关联中的作用尚不清楚。Javier Lozano-Bartolomé等人则研究了miR-181a-5p和miR-23a-3p在肥胖中的表达谱并研究它们脂肪细胞中TNFα诱导的IR中作用，并将相关结果发表在近日的JCEM上。

大家都知道促炎细胞因子TNFα是胰岛素抵抗（IR）的关键因素。虽然一些miRNA被认为与脂肪组织（AT）IR的发展有关，但是miRNA在炎症与IR之间的关联中的作用尚不清楚。Javier Lozano-Bartolomé等人则研究了miR-181a-5p和miR-23a-3p在肥胖中的表达谱并研究它们脂肪细胞中TNFα诱导的IR中作用，并将相关结果发表在近日的JCEM上。

研究人员将受试者分成2个队列。队列1用于研究AT表达，包括28名BMI <30的受试者和30名BMI≥30的受试者。队列2用于循环血清miRNA的研究，包括101名4年随访的受试者（48例和53例对照）。在皮下（SAT）和内脏（VAT）AT中评估miR-181a-5p和miR-23a-3p表达。使用miRNA模拟物和抑制剂在脂肪细胞中进行功能分析。分析胰岛素途径的关键分子AKT，PTEN，AS160和S6K。

结果显示来自肥胖和糖尿病受试者的AT中miR-181a-5p和miR-23a-3p的表达降低，并且与肥胖和HOMA-IR呈负相关。在脂肪细胞中miR-181a-5p和miR-23a-3p的过度表达上调了胰岛素刺激的AKT活化并降低了TNFα诱导的IR，从而调节PTEN和S6K表达。与对照组相比，病例组基线水平血清miR-181a-5p水平降低，指向其预后价值。投影评分变量的重要性表明，miR-181a-5p在120分钟时比胰岛素或葡萄糖对模型的影响更大。

上述研究表明miR-181a-5p和miR-23a-3p可以通过调节PTEN和S6K的表达来阻止TNFα诱导的脂肪细胞的IR。

原始出处：

Javier Lozano-Bartolomé.et al. Altered expression of miR-181a-5p and miR-23a-3p is associated with obesity and TNFα-induced insulin resistance . J Clin Endocrinol Metab. 2017.

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    2018-12-25 achengzhao

    #JCE#

    0

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    2018-09-23 baoya

    #胰岛#

    0

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    2018-07-29 smallant2002

    #miR#

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    2018-06-05 smallant2015

    #JCEM#

    0

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    2018-02-10 Jackie Li

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2063153, encodeId=b507206315324, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Dec 25 05:36:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749923, encodeId=421a1e4992317, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Sep 23 15:36:00 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930582, encodeId=ac0d1930582c6, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Jul 29 21:36:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777771, encodeId=13c41e77771ef, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Jun 05 02:36:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286742, encodeId=4487286e424b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Feb 10 09:10:30 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286613, encodeId=d6812866131d, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Fri Feb 09 22:24:56 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286592, encodeId=284f2865926f, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Feb 09 21:45:55 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 orangesking

    好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2063153, encodeId=b507206315324, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Dec 25 05:36:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749923, encodeId=421a1e4992317, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Sep 23 15:36:00 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930582, encodeId=ac0d1930582c6, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Jul 29 21:36:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777771, encodeId=13c41e77771ef, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Jun 05 02:36:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286742, encodeId=4487286e424b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Feb 10 09:10:30 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286613, encodeId=d6812866131d, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Fri Feb 09 22:24:56 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286592, encodeId=284f2865926f, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Feb 09 21:45:55 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 1e0f8808m18(暂无匿称)

    学习了.谢谢分享

    0