心梗后舒张压<70 mmHg有危险!欧洲心脏杂志研究称:这类患者更需再灌注治疗

2020-06-09 xujing 中国循环杂志

近日,《欧洲心脏杂志》发表的EPHESUS研究的亚组分析结果显示,如果心肌梗死后舒张压低于70 mmHg,再有心衰症状和体征,应及时接受血运重建,否则不良心血管事件及死亡风险明显增加。

近日,《欧洲心脏杂志》发表的EPHESUS研究的亚组分析结果显示,如果心肌梗死后舒张压低于70 mmHg,再有心衰症状和体征,应及时接受血运重建,否则不良心血管事件及死亡风险明显增加。

研究者提醒,临床上应高度重视这类患者,因为舒张压较低以及冠状动脉严重狭窄可能导致心肌灌注压异常,而血运重建可能对维持冠状动脉灌注压力特别重要。

图 再灌注通过维持灌注压消除了低舒张压带来的风险

研究发现,低舒张压时,心血管死亡或心血管住院治疗、全因死亡和心血管死亡发生率均较高。一般来说,与血运重建后相比,无血运重建患者事件发生率更高。

研究发现,对于没有血运重建的患者,如舒张压<70mmhg,则全因死亡风险增加80%、心血管死亡风险增加70%、心血管死亡或心血管住院风险增加54%。

而在接受血运重建的患者中未观察到舒张压低相关的不良心血管事件风险增加。

收缩压低时,不良心血管事件风险增加与血运重建无关。

收缩压为120~130 mmHg的患者亚组的敏感性分析显示,在低舒张压时,血运重建显着降低不良心血管事件风险。

研究纳入5929例急性心肌梗死后左心功能受损、有心衰症状及体征的患者。

舒张压较低的患者年龄较大,多为男性,体重指数较低,收缩压较低。血压较低的患者接受更多的血管重建手术。两组间心率无差异。

来源:B?hm M, Ferreira JP, Mahfoud F, et al. Myocardial reperfusion reverses the J-curve association of cardiovascular risk and diastolic blood pressure in patients with left ventricular dysfunction and heart failure after myocardial infarction: insights from the EPHESUS trial. Eur Heart J. 2020;41(17):1673‐1683.

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