J Rheumatol:托珠单抗对类风湿性关节炎的疗效不受合并症或肥胖的影响

2020-01-18 xiangting MedSci原创

在这项现实世界的分析中,TCZ常被用于治疗合并症负担重或肥胖患者。TCZ的疗效不受合并症或肥胖状况的影响。

合并症和肥胖可能会影响类风湿性关节炎患者(RA)的治疗反应。现实生活中很少有评估合并症负担或肥胖对托珠单抗(TCZ)疗效影响的研究。这项研究评估了在美国临床实践中,TCZ对高合并症负担vs 低合并症负担与肥胖vs非肥胖RA患者的疗效。

采用改良的Charlson合并症指数(mCCI)将Corrona RA注册研究中开始TCZ治疗的患者进行分层,分为低合并症或高合并症负担。使用体重指数(BMI),分为肥胖或非肥胖状态。调整基线特征的统计学显著差异后,比较上述患者开始TCZ治疗后6个月和12个月疾病活动性和功能的改善。

确定了接受TCZ治疗的高合并症(mCCI≥2n=195)和低合并症负担患者(mCCI<2n=575),和被分类为肥胖(BMI≥30n=356)和非肥胖的患者(BMI<30n=449)。大多数患者(>95%)曾经使用生物制剂,大约三分之一的患者接受TCZ单药治疗,患者间的合并症负担或肥胖状况无明显差异。不论合并症负担或肥胖状况如何,两组在6个月和12个月时的疾病活动性和功能改善相似。

在这项现实世界的分析中,TCZ常被用于治疗合并症负担重或肥胖患者。TCZ的疗效不受合并症或肥胖状况的影响。

原始出处:

Dimitrios A. Pappas. Effectiveness of Tocilizumab in Patients With Rheumatoid Arthritis is Unaffected by Comorbidity Burden or Obesity: Data From a US Registry. J Rheumatol. January 2020.

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    2020-01-20 lmm397
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    2020-01-18 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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