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J Clin Oncol：转移性鳞状非小细胞肺癌患者中使用卡铂-紫杉醇联合培博利珠单抗可改善患者的生活质量

2020-08-19 MedSci原创 MedSci原创

转移性非鳞状非小细胞肺癌培博利珠单抗
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在3期KEYNOTE-407研究中，在卡铂-紫杉醇/纳博-紫杉醇的基础上加用培博利珠单抗可显著改善既往未经治疗的转移性鳞状非小细胞肺癌（NSCLC）患者的总生存期、无进展生存期和客观反应率，但对严重毒

在3期KEYNOTE-407研究中，在卡铂-紫杉醇/纳博-紫杉醇的基础上加用培博利珠单抗可显著改善既往未经治疗的转移性鳞状非小细胞肺癌（NSCLC）患者的总生存期、无进展生存期和客观反应率，但对严重毒性影响不大。本文中，我们介绍了KEYNOTE-407的患者报告结果（PRO）。

患者随机接受4个周期的培博利珠单抗 200 mg或安慰剂，每3周一次，再加上卡铂加紫杉醇或nab-紫杉醇，然后再接受培博利珠单抗或安慰剂，共31个周期。使用欧洲癌症研究与治疗组织的癌症治疗生活质量问卷-核心30（QLQ-C30）和生活质量问卷-肺癌模块13（QLQ-LC13）评估健康相关的生活质量（HRQoL）。关键的PRO终点是QLQ-C30全球健康状况/生活质量(GHS/QoL)评分从基线到第9周和第18周(铂金治疗期间和之后)的变化，以及QLQ-C30和QLQ-LC13的咳嗽、胸痛或呼吸困难的复合终点恶化时间。

 

结果，共有554和553名患者分别完成了≥1次QLQ-C30或≥1次QLQ-LC13评估。培博利珠单抗联合组的GHS/QoL评分有所改善（与基线相比的最小二乘法[LS]平均值[95%CI]变化：第9周，1.8[-0.9～4.4]；第18周，4.3[1.7～6.9]），安慰剂联合组的GHS/QoL评分有所恶化（第9周，-1.8[-4.4～0.7]；第18周，-0.57[-3.3～2.2]）。培博利珠单抗联合组的组间差异得到改善（LS平均评分差异：第9周，3.6[95% CI，0.3～6.9]，P = .037；第18周，4.9[1.4～8.3]，P = .0060）。两组均未达到咳嗽、胸痛或呼吸困难恶化的中位时间（HR，0.79；95% CI，0.58～1.06]；P = .125）。

综上所述，该研究结果表明，在化疗中加入培博利珠单抗可维持或改善相对于基线的HRQoL测量值，并在第9周和第18周改善HRQoL与单独化疗的比较。这些结果支持使用培博利珠单抗加化疗作为转移性鳞状NSCLC的一线治疗。

 

原始出处：

 

Julien Mazieres, Dariusz Kowalski, et al., Health-Related Quality of Life With Carboplatin-Paclitaxel or nab-Paclitaxel With or Without Pembrolizumab in Patients With Metastatic Squamous Non-Small-Cell Lung Cancer. J Clin Oncol. 2020 Jan 20;38(3):271-280. doi: 10.1200/JCO.19.01348. 

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10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2021-05-31 minlingfeng

    #Oncol#

    0

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    2020-10-07 柳叶一刀

    #铂#

    0

  3. 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10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2021-05-28 lingaifan

    #非小细胞#

    0

  4. 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encryptionId=37fd93443d0, topicName=转移性鳞状非小细胞肺癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat May 29 20:43:57 CST 2021, time=2021-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386652, encodeId=d2ef138665266, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396303, encodeId=9006139630332, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600884, encodeId=89d016008843a, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-10-05 gds2009

    #肺癌患者#

    0

  5. 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encodeId=9006139630332, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600884, encodeId=89d016008843a, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-30 ms3000000449926787

    学习了

    0

  6. 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encodeId=9006139630332, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600884, encodeId=89d016008843a, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2021-05-29 12498d2fm51(暂无昵称)

    #转移性鳞状非小细胞肺癌#

    0

  7. 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encodeId=9006139630332, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600884, encodeId=89d016008843a, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-21 1249842em09(暂无昵称)

    #转移性#

    0

  8. 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encodeId=9006139630332, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600884, encodeId=89d016008843a, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Fri Aug 21 10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-21 智者为医08

    #卡铂#

    0

  9. 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10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-21 zxxiang

    #非小细胞肺癌患者#

    0

  10. 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10:43:57 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038095, encodeId=5a7710380951a, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Aug 19 22:43:57 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-19 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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