Clin Gastroenterol H:肝脏脂肪与炎症和氧化应激标志物相关联

2018-12-03 xing.T MedSci原创

由此可见,在基于社区的队列中,没有已知肝脏疾病的肝脏脂肪变性患者具有更高的全身炎症标志物血清浓度。需要进一步研究以确定肝脂肪变性的治疗是否会减轻全身炎症。

非酒精性脂肪肝病是一种导致进行性肝病的炎症。目前尚不清楚患有肝脏脂肪变性,但未患有肝脏疾病的个体是否有较高的全身性炎症和氧化应激标志物血清浓度。

近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员收集了来自Framingham心脏研究(平均年龄为51±11岁;51%为女性)的2482名参与者的数据,他们接受了计算机断层扫描和14种全身炎症血清标志物的测量。重度饮酒受试者被排除在外。肝脏模体比(LPR,相对于校准体模的肝衰减的连续参数)用于确定具有肝脏脂肪的影像学证据的个体。主要协变量包括年龄、性别、吸烟、酒精、服用阿司匹林、高血压、血脂异常、糖尿病血管疾病。体重指数和内脏脂肪是次要协变量。研究人员使用多变量线性回归模型来评估肝脏脂肪和全身炎症标志物之间的关联。

在多变量校正模型中,肝脏脂肪与以下炎症标志物相关:高敏C反应蛋白(P<0.001)、尿异前列腺素(P<0.001)、白细胞介素6(P<0.001)、细胞间粘附分子1(P<0.001)和P-选择蛋白(P=0.002)。体重指数或内脏脂肪的额外调整使相关性略微减弱,尽管所有关联仍然具有统计学意义(所有P≤0.01)。

由此可见,在基于社区的队列中,没有已知肝脏疾病的肝脏脂肪变性患者具有更高的全身炎症标志物血清浓度。需要进一步研究以确定肝脂肪变性的治疗是否会减轻全身炎症。

原始出处:

Zachary P. Fricker,et al.Liver Fat is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study. Clinical gastroenterology and hepatology.2018.https://www.cghjournal.org/article/S1542-3565(18)31280-1/fulltext

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    2019-01-30 许安

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