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Haematologica：研究发现TGFβ1是引起骨髓增生异常综合征和急性髓系白血病间充质干细胞的功能性抑制触发因子

2018-06-24 MedSci MedSci原创

Tgfβ1白血病间充质干细胞制触发因子
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间充质基质细胞参与骨髓增生异常综合征和急性髓细胞白血病的发病机制，但其潜在机制尚不完全清楚。为了进一步表征病理学表型，我们对来自骨髓增生异常综合征和急性骨髓性白血病患者的间充质基质细胞进行了RNA测序，揭示了通常在骨髓增生异常综合征和急性骨髓性白血病中表达异常的基因的特定分子标记。通路分析显示，与骨生成、衰老、炎症和抑制性细胞因子有关的基因的强烈富集，从而在分子水平上反映骨髓增生异常综合征和急性髓

间充质基质细胞参与骨髓增生异常综合征和急性髓细胞白血病的发病机制，但其潜在机制尚不完全清楚。为了进一步表征病理学表型，我们对来自骨髓增生异常综合征和急性骨髓性白血病患者的间充质基质细胞进行了RNA测序，揭示了通常在骨髓增生异常综合征和急性骨髓性白血病中表达异常的基因的特定分子标记。

通路分析显示，与骨生成、衰老、炎症和抑制性细胞因子有关的基因的强烈富集，从而在分子水平上反映骨髓增生异常综合征和急性髓性白血病中间质基质细胞的结构和功能缺陷。进一步分析确定TGFβ1是这种异常表达基因最可能的外在触发因子。

在暴露于TGFβ1之后，健康的间充质基质细胞出现功能缺陷和表现型与患者衍生的基质细胞中观察到的表型相同。 TGF-β1对基质细胞功能的这些抑制作用被已确定的TGFβ受体信号传导抑制剂SD-208所抵消。通过SD-208阻断TGFβ信号还恢复了患者来源的基质细胞的成骨分化能力，从而证实了TGFβ1在患有骨髓增生异常综合征和急性髓性白血病的患者的骨髓微环境中的作用。

综上所述，该研究结果建立了TGFβ1作为引起骨髓增生异常综合征和急性髓细胞性白血病中MSC的功能性抑制的相关触发因子，并鉴定SD-208为恢复这些效应的候选者。

原始出处：

Geyh S, Rodríguez-Paredes M, et al., TGFβ1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia. Haematologica. 2018 May 17. pii: haematol.2017.186734. doi: 10.3324/haematol.2017.186734. 

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    2018-10-14 fangcong

    #髓系白血病#

    0

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    2019-02-14 xlxchina

    #功能性#

    0

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    2018-10-10 h.y200607_23674418

    #间充质干细#

    0

  4. 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createdName=xlxchina, createdTime=Thu Feb 14 17:17:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815340, encodeId=72f118153409a, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Oct 10 06:17:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035871, encodeId=337c20358e109, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Sep 27 08:17:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035808, encodeId=d48c2035808d1, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Jul 28 23:17:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821879, encodeId=33dc18218e9db, content=<a href='/topic/show?id=7db310196345' target=_blank style='color:#2F92EE;'>#骨髓增生异常综合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101963, encryptionId=7db310196345, topicName=骨髓增生异常综合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Nov 15 15:17:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008372, encodeId=48e920083e2c7, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Mar 26 09:17:00 CST 2019, time=2019-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753415, encodeId=92d61e53415b6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-09-27 changhe713

    #TGF#

    0

  5. 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href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-07-28 yuanming7

    #TGFβ#

    0

  6. 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href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-11-15 xinmeili

    #骨髓增生异常综合#

    0

  7. 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encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Sep 27 08:17:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035808, encodeId=d48c2035808d1, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Jul 28 23:17:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821879, encodeId=33dc18218e9db, content=<a href='/topic/show?id=7db310196345' target=_blank style='color:#2F92EE;'>#骨髓增生异常综合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101963, encryptionId=7db310196345, topicName=骨髓增生异常综合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Nov 15 15:17:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008372, encodeId=48e920083e2c7, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Mar 26 09:17:00 CST 2019, time=2019-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753415, encodeId=92d61e53415b6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2019-03-26 changfy

    #HAE#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1822069, encodeId=26f4182206980, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Sun Oct 14 20:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915477, encodeId=705b19154e759, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Feb 14 17:17:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815340, encodeId=72f118153409a, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Oct 10 06:17:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035871, encodeId=337c20358e109, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Sep 27 08:17:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035808, encodeId=d48c2035808d1, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Jul 28 23:17:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821879, encodeId=33dc18218e9db, content=<a href='/topic/show?id=7db310196345' target=_blank style='color:#2F92EE;'>#骨髓增生异常综合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101963, encryptionId=7db310196345, topicName=骨髓增生异常综合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Nov 15 15:17:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008372, encodeId=48e920083e2c7, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Mar 26 09:17:00 CST 2019, time=2019-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753415, encodeId=92d61e53415b6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-11-19 hanhaisha2020

    #研究发现#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1822069, encodeId=26f4182206980, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Sun Oct 14 20:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915477, encodeId=705b19154e759, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Feb 14 17:17:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815340, encodeId=72f118153409a, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Oct 10 06:17:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035871, encodeId=337c20358e109, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Sep 27 08:17:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035808, encodeId=d48c2035808d1, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Jul 28 23:17:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821879, encodeId=33dc18218e9db, content=<a href='/topic/show?id=7db310196345' target=_blank style='color:#2F92EE;'>#骨髓增生异常综合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101963, encryptionId=7db310196345, topicName=骨髓增生异常综合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Nov 15 15:17:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008372, encodeId=48e920083e2c7, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Mar 26 09:17:00 CST 2019, time=2019-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753415, encodeId=92d61e53415b6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2019-05-27 yangeasy

    #Tgfβ1#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1822069, encodeId=26f4182206980, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Sun Oct 14 20:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915477, encodeId=705b19154e759, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101963, encryptionId=7db310196345, topicName=骨髓增生异常综合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Nov 15 15:17:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008372, encodeId=48e920083e2c7, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Mar 26 09:17:00 CST 2019, time=2019-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753415, encodeId=92d61e53415b6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Nov 19 09:17:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995775, encodeId=5a8d1995e755c, content=<a href='/topic/show?id=b4f31e357b8' target=_blank style='color:#2F92EE;'>#Tgfβ1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17357, encryptionId=b4f31e357b8, topicName=Tgfβ1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon May 27 17:17:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821760, encodeId=e35a1821e60f6, content=<a href='/topic/show?id=d1ba10196122' target=_blank style='color:#2F92EE;'>#骨髓增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101961, encryptionId=d1ba10196122, topicName=骨髓增生)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=fengyqf, createdTime=Sun Oct 14 02:17:00 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-10-14 fengyqf

    #骨髓增生#

    0

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转化生长因子β1（Tgfβ1）在肿瘤中扮演着重要角色。绝大部分Tgfβ1来自血小板。CLIN CANCER RES近期发表了一篇文章，研究血小板Tgfβ1在卵巢癌进展中发挥的作用以及这种作用是否仅限与远处转移还是与原发肿瘤生长也有关系。

CLIN CANCER RES：TGFβ1基因变异预测HPV阳性口咽癌患者根治性放疗后临床结局

TGFβ1在炎症反应，免疫反应，治疗反应和患者预后中起到关键作用。TGFβ1变异可能会影响其表达水平或功能，从而调节肿瘤状态，影响HPV阳性口咽鳞状细胞癌（SCCOP）患者生存。CLIN CANCER RES近期发表了一篇文章研究这一问题。