Eur Respir J:慢性呼吸道疾病是COVID-19患者严重结局的预测指标

2021-05-28 MedSci原创 MedSci原创

既往有呼吸系统疾病的患者因COVID-19住院的可能性比流行性感冒要低,但罹患严重COVID-19的风险更高,并且与流感患者和无呼吸系统疾病史的患者相比,其死亡率更高。

最初,流行性感冒被认为是COVID-19流行的合适模型,但缺乏慢性呼吸道疾病(CRD)患者的数据,这些患者被认为可能患严重COVID-19。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,这项全国性的回顾性队列研究描述了因COVID-19(2020年3月至4月)或流感(2018-2019年流感爆发)而住院的肺部疾病患者。研究人员比较了由此产生的肺部并发症、需要接受重症监护和院内死亡率。

在89530名COVID-19病例中,16.03%的患者至少有1种CRD,其发生频率明显低于45819例季节性流感患者。与患有肺癌、睡眠呼吸暂停、肺气肿和间质性肺病(ILD)的患者相反,患有慢性呼吸衰竭、慢性阻塞性肺疾病、哮喘、囊性纤维化和肺动脉高压患者代表性不足。

结局比较

与流感患者相比,伴有CRD的COVID-19患者发生的呼吸机相关性肺炎和肺栓塞明显增加。当与没有CRD的COVID-19患者或流感患者相比,他们需要重症监护的频率更高,死亡率更高(哮喘除外)。

由此可见,既往有呼吸系统疾病的患者因COVID-19住院的可能性比流行性感冒要低,但罹患严重COVID-19的风险更高,并且与流感患者和无呼吸系统疾病史的患者相比,其死亡率更高。

原始出处:

Guillaume Beltramo,et al.Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study.Eur Respir J.2021.https://erj.ersjournals.com/content/early/2021/05/06/13993003.04474-2020

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