Sci Rep:氯胺酮滥用调查以及与下尿路症状关系研究

2019-05-23 AlexYang MedSci原创

最近,有研究人员探索了氯胺酮滥用与下尿路症状(LUTS)之间的关系,并调查了氯胺酮膀胱炎的流行病学。研究人员从2个私人康复中心中获取了关于氯胺酮滥用者的相关信息,包括性别、年龄和使用氯胺酮的细节,以及消费方式、用量和氯胺酮使用的时间和LUTS情况。研究总共有106名滥用者完成了调查问卷。结果表明,氯胺酮滥用者在滥用24.67±26.36个月时出现LUTS症状。膀胱过度活动症状评分、国际前列腺症状评

最近,有研究人员探索了氯胺酮滥用与下尿路症状(LUTS)之间的关系,并调查了氯胺酮膀胱炎的流行病学。

研究人员从2个私人康复中心中获取了关于氯胺酮滥用者的相关信息,包括性别、年龄和使用氯胺酮的细节,以及消费方式、用量和氯胺酮使用的时间和LUTS情况。研究总共有106名滥用者完成了调查问卷。结果表明,氯胺酮滥用者在滥用24.67±26.36个月时出现LUTS症状。膀胱过度活动症状评分、国际前列腺症状评分、间质性膀胱炎症状指数、间质性膀胱炎问题指数和视觉模拟评分分别为5.25±4.43、5.95±5.72、10.96±6.66、9.73±5.82和2.55±3.1。所有的症状得分均与氯胺酮滥用时间呈现正相关关系。与烟雾形式使用相比,氯胺酮吸食与所有的症状得分显著相关。另外,氢化膨胀、透明质酸膀胱灌、肉毒毒素膀胱内注射和高压氧治疗表现出了比口腔治疗更好的效果。氯胺酮能够诱导严重的症状积累,比如夜尿和高频率依赖于氯胺酮滥用的时间。氯胺酮吸食可能引起了比烟雾形式更严重的LUTS。氯胺酮和其他药物的组合使用能够加速LUTS。

最后,研究人员指出,膀胱内治疗可能要比口服药物治疗产生更好的治疗效果。

原始出处:

Chiao-Ching Li, Sheng-Tang Wu, Tai-Lung Cha et al. A survey for ketamine abuse and its relation to the lower urinary tract symptoms in Taiwan. Sci Rep. 10 May 2019

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    2020-01-08 zchen
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    2019-05-25 jml2009
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