Crit Care：血小板储存时间与临床和输血结局的关系

2018-08-05 xing.T MedSci原创

由此可见，PLT储存时间似乎与危重病人或血液病患者的临床结局无关，包括出血、败血症或死亡。最新鲜的PLT（不到3天）与更好的CCI相关，尽管对出血事件没有影响。然而，没有证据可以得出明确的结论，特别是在危重病人中。

血小板（PLT）通常在输血前储存长达5天，但在某些血液服务中，储存期延长至7天。在储存期间，PLT和存储介质都发生变化，这可能导致PLT激活和功能障碍。这些变化的临床意义尚不确定。近日，危重病医学领域权威杂志Critical Care上发表了一篇研究文章，研究人员进行了一项荟萃分析旨在评估PLT储存时间与接受同种异体PLT输血的患者的临床或输血结局之间的关联。

研究人员检索了MEDLINE、Embase、PubMed和Cochrane图书馆等数据库确定了2000年1月至2017年7月期间以英文发表的研究。在所确定的18项研究中，5项研究包含了4719名危重病人（创伤、心脏手术术后和危重病人的异质人群）以及13项研究包含了8569名血液病患者。

在重症患者中进行的5项研究是回顾性的，并且没有发现PLT储存时间长达5天与死亡率之间存在任何关联。在2项最大的研究中，储存时间较长的PLT与败血症之间也没有发现存在关联（n=4008例患者）。在血液病患者中进行的13项研究中，7项研究分析了长达6.5或7天的延长储存时间。在分析该结局的8项研究中的7项研究表明与储存时间较长的PLT相比，输入新鲜的PLT（少于2或3天）与校正后计数增量（CCI）的显著增加相关。1项单中心回顾性研究发现输入储存时间较长PLT的患者出血事件增多。

由此可见，PLT储存时间似乎与危重病人或血液病患者的临床结局无关，包括出血、败血症或死亡。最新鲜的PLT（不到3天）与更好的CCI相关，尽管对出血事件没有影响。然而，没有证据可以得出明确的结论，特别是在危重病人中。

原始出处：

Cécile Aubron.et al. Platelet storage duration and its clinical and transfusion outcomes: a systematic review.Critical Care.2018. https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-2114-x

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2019-03-15 Luyuxie_9

#输血结局#

28 0
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2018-08-13 1e17414fm02(暂无匿称)

学习

111 0
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2018-08-07 windight

#输血#

24 0
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2018-08-07 飛歌

学习了很有用

70 0
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2018-08-06 131****2916

不错的文章值得推荐一下

66 0
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2018-08-06 龙胆草

学习谢谢分享

72 0
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2018-08-06 phoebeyan520

学习学习，谢谢分享

62 0
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2018-08-06 jihuaijun1112

学习学习学习

24 0
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2018-08-06 wqkm

^_^^_^^_^

30 0
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2018-08-06 明月清辉

谢谢分享，学习了

29 0