Exp Ther Med:正常眼压性青光眼的发病机制和遗传因素综述

2019-02-11 MedSci MedSci原创

希腊雅典Konstantopouleio-Patission综合医院眼科的Trivli A等人近日在Exp Ther Med杂志上发表了一篇综述文章,作者系统总结了正常眼压性青光眼的发病机制及遗传因素等。

希腊雅典Konstantopouleio-Patission综合医院眼科的Trivli A等人近日在Exp Ther Med杂志上发表了一篇综述文章,作者系统总结了正常眼压性青光眼的发病机制及遗传因素等。

正常眼压性青光眼(NTG)是一种多因素视神经病变,与开角型青光眼的特征相似,其临床特征主要是进行性视网膜神经节细胞死亡和青光眼视野逐渐丧失。NTG与开角型青光眼的主要区别是NTG的眼压(IOP)在正常范围内。目前,NTG缺乏主要的危险预测因素和治疗方案,其升高的眼压也对NTG的临床治疗提出了挑战。

关于NTG的病理生理学研究已经发表了几篇有见地的论文,研究者描述了可能的致病机制。目前的文献表明,相当比例的NTG患者(高达21%)有青光眼家族病史,表明该疾病具有遗传易感性。

已有研究使得人们对NTG发病过程变大更加模糊不清。这篇综述总结了与NTG发展有关的血管、分子机制和遗传因素等,并讨论它们参与NTG发病过程的机制。

原文出处:

Trivli, A., et al., Normal-tension glaucoma: Pathogenesis and genetics. Exp Ther Med, 2019. 17(1): p. 563-574.

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    2019-02-13 swallow
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    2019-02-11 lietome24

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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