JCEM:2型糖尿病与总髋骨面积和骨密度变化的关系

2021-07-03 MedSci原创 MedSci原创

与非T2DM患者相比,新发T2DM患者全髋骨面积的扩张程度较低。

在一项横断面研究中,研究人员发现2型糖尿病(T2DM)与较小的骨面积以及较高的全髋骨矿物质密度(BMD)之间存在关联。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在纵向探究这些关联,通过研究与T2DM状态相关的总髋骨面积和BMD变化情况。

在三个队列中,瑞典乳腺X线摄影队列临床研究(SMCC;n=1060)、乌普萨拉老年人血管系统的前瞻性调查研究(PIVUS;n=483)和乌普萨拉成年男性纵向研究(ULSAM;n=203),研究人员重复评估了受试者的T2DM状态和双能X射线骨密度仪(DXA)测量的总髋骨面积,以及8年间的平均BMD。研究人员使用线性回归模型评估T2DM状态对全髋骨面积和BMD变化的影响。

基线、随访和评估间全髋骨面积和骨密度变化情况

经过荟萃分析,与非T2DM患者相比,T2DM患者的全髋骨面积变化减少0.5%(-0.18 cm2 [95%CI为-0.30, -0.06])。与非T2DM患者相比,T2DM患者的骨面积变化相似(0.00 cm2 [95%CI为-0.13, 0.13])。对于BMD,与非T2DM患者相比,新发T2DM的患者综合估计值为0.004 g/cm2 (95%CI为-0.006, 0.014),已患T2DM的患者综合估计值为0.010 g/cm2 (95%CI为-0.000, 0.020)。

由此可见,与非T2DM患者相比,新发T2DM患者全髋骨面积的扩张程度较低

原始出处:

Adam Mitchell.et al.Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women.JCEM.2021.https://doi.org/10.1210/clinem/dgab490

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    2022-01-01 achengzhao
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    2021-08-24 smallant2015
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    2021-09-08 病毒猎手

    #糖尿病##骨密度#关联!!

    0

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    2021-07-04 63766754

    再次努力学习

    0

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    2021-07-03 misszhang

    谢谢MedSci提供最新的资讯

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