Circulation:髓系或全身CD39过表达保护脑缺血

2017-04-11 MedSci MedSci原创

炎症发生和血栓形成会加剧局部缺血事件发生后导致的脑组织损伤。细胞外ATP和ADP水平升高与细胞损伤、炎症发生和血栓形成有关。在白细胞和内皮细胞膜上表达的核苷三磷酸二磷酸水解酶-1(即CD39),通过磷酸水解ATP/ADP抑制血小板活化和白细胞浸润。近期美国学者发表研究文章于著名血管杂志Circulation,以研究CD39增加在在体脑缺血模型中的作用。研究构建了表达人CD39(hCD39)的转基因

炎症发生和血栓形成会加剧局部缺血事件发生后导致的脑组织损伤。细胞外ATP和ADP水平升高与细胞损伤、炎症发生和血栓形成有关。在白细胞和内皮细胞膜上表达的核苷三磷酸二磷酸水解酶-1(即CD39),通过磷酸水解ATP/ADP抑制血小板活化和白细胞浸润。

近期美国学者发表研究文章于著名血管杂志Circulation,以研究CD39增加在在体脑缺血模型中的作用。研究构建了表达人CD39(hCD39)的转基因小鼠。

与野生型小鼠相比,全身hCD39转基因小鼠(n = 9)和髓系CD39-过表达小鼠(n = 6)脑梗死体积明显减小。使用流式细胞术分析缺血侧和对侧脑半球的白细胞。虽然对侧脑半球具有相同数量的巨噬细胞和嗜中性粒细胞,但全身hCD39转基因小鼠的缺血侧脑半球浸润较少(n = 4)。与野生型小鼠相比,转基因小鼠有较少的神经功能损伤(n = 6)。

本研究首次报道在小鼠体内CD39过表达可保护机体防止卒中,减少白细胞浸润、梗死体积以及神经功能缺损。全身或髓系细胞中CD39过表达抑制缺血后白细胞浸润,减少卒中诱发的神经损伤。

原始出处: 


Baek AE,Sutton NR ,et al.Ischemic Cerebroprotection Conferred by Myeloid Lineage-Restricted or Global CD39 Transgene Expression. Circulation. 2017 Apr 4. pii: CIRCULATIONAHA.116.023301.

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    2017-12-07 lq1767
  2. [GetPortalCommentsPageByObjectIdResponse(id=1958157, encodeId=bcea195815e85, content=<a href='/topic/show?id=48a294126c0' target=_blank style='color:#2F92EE;'>#过表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94126, encryptionId=48a294126c0, topicName=过表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Thu Dec 07 11:10:00 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193832, encodeId=3540193832f7, content=细胞外ATP和ADP水平升高与细胞损伤、炎症发生和血栓形成有关。体内CD39过表达可保护机体防止卒中,减少白细胞浸润、梗死体积以及神经功能缺损。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:16:18 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289191, encodeId=d7ab1289191e0, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Apr 12 15:10:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538799, encodeId=d3f61538e997e, content=<a href='/topic/show?id=e9cd432219' target=_blank style='color:#2F92EE;'>#CD39#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4322, encryptionId=e9cd432219, topicName=CD39)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=564813056045, createdName=yhj-time, createdTime=Wed Apr 12 15:10:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
    2017-05-04 ayl3691

    细胞外ATP和ADP水平升高与细胞损伤、炎症发生和血栓形成有关。体内CD39过表达可保护机体防止卒中,减少白细胞浸润、梗死体积以及神经功能缺损。

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1958157, encodeId=bcea195815e85, content=<a href='/topic/show?id=48a294126c0' target=_blank style='color:#2F92EE;'>#过表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94126, encryptionId=48a294126c0, topicName=过表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Thu Dec 07 11:10:00 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193832, encodeId=3540193832f7, content=细胞外ATP和ADP水平升高与细胞损伤、炎症发生和血栓形成有关。体内CD39过表达可保护机体防止卒中,减少白细胞浸润、梗死体积以及神经功能缺损。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:16:18 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289191, encodeId=d7ab1289191e0, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Apr 12 15:10:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538799, encodeId=d3f61538e997e, content=<a href='/topic/show?id=e9cd432219' target=_blank style='color:#2F92EE;'>#CD39#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4322, encryptionId=e9cd432219, topicName=CD39)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=564813056045, createdName=yhj-time, createdTime=Wed Apr 12 15:10:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
    2017-04-12 yhj-time