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Circulation：下肢动脉血栓形成后癌症的风险与预后！

2018-03-19 xing.T MedSci原创

下肢动脉血栓形成癌症风险预后
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由此可见，下肢动脉血栓形成是隐匿性癌症，尤其是肺癌的标志物，是常见癌症死亡率的不利预后因素。

静脉血栓栓塞可能是癌症的表现症状，但下肢动脉血栓形成与癌症之间的关系尚不清楚。近日，心血管领域权威杂志Circulation上发表了一篇研究文章，研究人员分析了下肢动脉血栓患者的癌症风险和预后。

研究人员利用全国性的丹麦卫生登记数据，确定了所有首次诊断为下肢动脉血栓（1994−2013）的患者，并随访至任何类型的癌症诊断、迁出、死亡或随访至2013年11月30日，以先到者为准。研究人员根据性别、年龄和时间的全国发病率，计算了标准化发病率以及95%可信区间（CIs）作为与预期数量相对应的癌症数目。为了评估下肢动脉血栓形成对癌症患者全因死亡预后的影响，研究人员组建了一个没有下肢动脉血栓形成的癌症患者匹配对照队列。

在6600例下肢动脉血栓形成的患者中，随访后发现了772例癌症患者。经过6个月的随访，任何癌症的风险为2.5%，20年后增加到17.9%。前6个月的随访期间，任何癌症的标准化发病比为3.28（95%可信区间：2.79-3.82）。在随访在7-12个月（1.42，95%可信区间为1.09-1.83）和超过12个月（1.14，95%可信区间为1.05-1.24）期间，标准化发病率持续升高。研究人员发现肺癌和其他与吸烟相关的癌症患者中相关性最强。下肢动脉血栓形成与结肠癌、肺癌、膀胱癌和乳腺癌的全因死亡率增加有关，但与前列腺癌无关。

由此可见，下肢动脉血栓形成是隐匿性癌症，尤其是肺癌的标志物，是常见癌症死亡率的不利预后因素。

原始出处：

Jens Sundbøll,et al. Risk and Prognosis of Cancer After Lower Limb Arterial Thrombosis. Circulation. 2018.  https://doi.org/10.1161/CIRCULATIONAHA.117.032617

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    2018-08-09 ms9833124466084992

    #动脉血#

    0

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    2018-04-05 zanzaifeng

    这个厉害了

    0

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    2018-10-10 swallow

    #下肢动脉#

    0

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    2018-03-26 wxl882001

    学习一下

    0

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    2018-03-21 yangcx0919

    #动脉血栓#

    0

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    2018-03-21 tonychen26

    #动脉血栓形成#

    0

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    2018-03-21 tonychen26

    #动脉血栓形成#

    0

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    2018-03-19 owlhealth

    不错耶.学习了

    0