Sci Rep:ABO血型不融合肾移植肾移植中选择性血浆置换研究

2020-02-09 AlexYang MedSci原创

自从2015年,有研究人员在ABO血型不融合肾移植前就进行了选择性血浆置换(SePE)进行分离性输血。最近,有研究人员将SePE分成2个小组,即只使用白蛋白组(组A)和部分的使用新鲜冷冻血浆组(组F),并并比较了两组之间的临床效果。研究总共包括了58次SePE(组A:n=41,组F:n=17),并且是在30名ABOi肾移植受试者中进行的。研究人员对异凝集素效价减少、血清IgG和IgM水平的变化以及

自从2015年,有研究人员在ABO血型不融合肾移植前就进行了选择性血浆置换(SePE)进行分离性输血。最近,有研究人员将SePE分成2个小组,即只使用白蛋白组(组A)和部分的使用新鲜冷冻血浆组(组F),并并比较了两组之间的临床效果。

研究总共包括了58次SePE(组A:n=41,组F:n=17),并且是在30名ABOi肾移植受试者中进行的。研究人员对异凝集素效价减少、血清IgG和IgM水平的变化以及凝血因子(纤维蛋白原、XIII因子)和副作用的发生率进行了回顾性的比较。研究发现,与组A相比,组F的异凝集素效价减少更加显著。免疫球蛋白和凝血因子在组F中得到了充分的补充。同时,副作用的发生率在组F中显著更高。另外,不考虑许多的副作用情况下,使用FFP(能够有效的减少异凝集素滴度,补充免疫球蛋白和凝血因子)的SePE可能是在ABO不融合肾移植前分离性输血的一种有益的治疗方式。

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    2020-07-07 yxch48
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    2020-02-11 TZF0804
  5. [GetPortalCommentsPageByObjectIdResponse(id=1742674, encodeId=b4811e42674af, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jul 07 01:09:00 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984286, encodeId=fba41984286a3, content=<a href='/topic/show?id=a35789001cc' target=_blank style='color:#2F92EE;'>#血型不融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89001, encryptionId=a35789001cc, topicName=血型不融合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Sat Oct 31 13:09:00 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922948, encodeId=e7021922948a7, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Tue May 19 08:09:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379330, encodeId=267813e9330c0, content=<a href='/topic/show?id=d4121e66e8' target=_blank style='color:#2F92EE;'>#ABO血型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1766, encryptionId=d4121e66e8, topicName=ABO血型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485788, encodeId=e7f21485e88f3, content=<a href='/topic/show?id=e75889215f7' target=_blank style='color:#2F92EE;'>#血浆置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89215, encryptionId=e75889215f7, topicName=血浆置换)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed838051612, createdName=12498e8em74暂无昵称, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525529, encodeId=98d5152552932, content=<a href='/topic/show?id=08548885835' target=_blank style='color:#2F92EE;'>#融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88858, encryptionId=08548885835, topicName=融合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08a911636812, createdName=licz0427, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598046, encodeId=bfc115980466e, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1742674, encodeId=b4811e42674af, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jul 07 01:09:00 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984286, encodeId=fba41984286a3, content=<a href='/topic/show?id=a35789001cc' target=_blank style='color:#2F92EE;'>#血型不融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89001, encryptionId=a35789001cc, topicName=血型不融合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Sat Oct 31 13:09:00 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922948, encodeId=e7021922948a7, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Tue May 19 08:09:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379330, encodeId=267813e9330c0, content=<a href='/topic/show?id=d4121e66e8' target=_blank style='color:#2F92EE;'>#ABO血型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1766, encryptionId=d4121e66e8, topicName=ABO血型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485788, encodeId=e7f21485e88f3, content=<a href='/topic/show?id=e75889215f7' target=_blank style='color:#2F92EE;'>#血浆置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89215, encryptionId=e75889215f7, topicName=血浆置换)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed838051612, createdName=12498e8em74暂无昵称, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525529, encodeId=98d5152552932, content=<a href='/topic/show?id=08548885835' target=_blank style='color:#2F92EE;'>#融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88858, encryptionId=08548885835, topicName=融合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08a911636812, createdName=licz0427, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598046, encodeId=bfc115980466e, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=)]
    2020-02-11 licz0427
  7. [GetPortalCommentsPageByObjectIdResponse(id=1742674, encodeId=b4811e42674af, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jul 07 01:09:00 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984286, encodeId=fba41984286a3, content=<a href='/topic/show?id=a35789001cc' target=_blank style='color:#2F92EE;'>#血型不融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89001, encryptionId=a35789001cc, topicName=血型不融合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Sat Oct 31 13:09:00 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922948, encodeId=e7021922948a7, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Tue May 19 08:09:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379330, encodeId=267813e9330c0, content=<a href='/topic/show?id=d4121e66e8' target=_blank style='color:#2F92EE;'>#ABO血型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1766, encryptionId=d4121e66e8, topicName=ABO血型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485788, encodeId=e7f21485e88f3, content=<a href='/topic/show?id=e75889215f7' target=_blank style='color:#2F92EE;'>#血浆置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89215, encryptionId=e75889215f7, topicName=血浆置换)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed838051612, createdName=12498e8em74暂无昵称, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525529, encodeId=98d5152552932, content=<a href='/topic/show?id=08548885835' target=_blank style='color:#2F92EE;'>#融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88858, encryptionId=08548885835, topicName=融合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08a911636812, createdName=licz0427, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598046, encodeId=bfc115980466e, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=)]
    2020-02-11 闆锋旦

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