Am J Gastroenterol:地中海式饮食可降低NAFLD患病率,改善NAFLD患者胰岛素抵抗

2017-11-25 MedSci MedSci原创

研究发现饮食与NAFLD患病率呈反比关系。在NAFLD患者中,良好的饮食习惯与低胰岛素抵抗有关。NAFLD患者,饮食可能是一种有益的营养方法。

研究背景:代谢性疾病(例如NAFLD)在西方国家高度流行,疾病的高度流行与生活方式、饮食习惯的改变有关。地中海式饮食(Med-Diet)对预防血管疾病是有效的,但与非酒精性脂肪性肝病(NAFLD)的关系很少被研究。

研究方法:本研究调查了584例有1项或者多项心血管危险因素(例如2型糖尿病、动脉性高血压、超重/肥胖、血脂异常)的门诊患者。使用超声诊断肝脂肪变性。采用经验性的半定量的九项饮食问卷对饮食依从性进行研究,患者依从性分为低、中度和高依从性。胰岛素抵抗被定义为HOMA-IR≥3.8。

研究结果:患者平均年龄为56.2±12.4岁,38.2%的患者为女性。87.2%的患者存在肝脂肪变性,肝脂肪变性的流行率随饮食依从性的由低到高而下降(96.5% vs. 71.4%, P<0.001)。在多元logistic回归分析中,高甘油三酯血症(优势比(OR): 2.913; P=0.002), log (ALT) (OR: 6.186; P<0.001), 饮食依从性(中度依从性vs.低依从性 OR: 0.115; P=0.041, 高度依从性vs.低依从性OR: 0.093; P=0.030),2型糖尿病(OR: 3.940; P=0.003),高腰围(OR: 3.012; P<0.001)与NAFLD相关。单一食物、低肉食摄入(OR: 0.178; P<0.001)与NAFLD呈负相关。334例非糖尿病NAFLD患者,年龄(OR: 1.035, P=0.025),高腰围(OR: 7.855, P<0.001)

高甘油三酯血症(OR: 2.152, P=0.011),Log (ALT) (OR: 2.549, P=0.002)直接与HOMA-IR相关,然而Med-Diet分数与NAFLD呈负相关(OR: 0.801, P=0.018).

研究结论:研究发现饮食与NAFLD患病率呈反比关系。在NAFLD患者中,良好的饮食习惯与低胰岛素抵抗有关。NAFLD患者,饮食可能是一种有益的营养方法。

原始出处
Baratta F, Pastori D, Polimeni L, et al. Adherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease: Effect on Insulin Resistance.Am J Gastroenterol, 2017, Oct 24. doi: 10.1038/ajg.2017.371.

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    2018-02-16 baoya
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    2018-08-14 lvygwyt2781
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    2018-04-29 许安
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    2017-11-27 wgx311