Hepatology:体力活动不足和久坐行为是非酒精性脂肪肝疾病的独立预测因子

2020-11-10 MedSci原创 MedSci原创

非酒精性脂肪肝疾病(NAFLD)是最常见的慢性肝病,在美国成年人中,其患病率接近30%。

        非酒精性脂肪肝疾病(NAFLD)是最常见的慢性肝病,在美国成年人中,其患病率接近30%。当前,尚无批准的用于治疗NAFLD和与NAFLD相关的晚期纤维化的治疗药物。因此,包括体育锻炼(PA),饮食变化和体重减轻在内的生活方式改变是优化NAFLD患者治疗的基石。然而PA可以有效地延缓NAFLD的进展,此外,PA升高可预防和/或延缓NAFLD相关和合并症相关疾病的进展,而与体重减轻无关。横断面研究表明,在调整了其他混杂因素后,NAFLD的患病率与PA呈反比关系。除了PA,久坐行为与2型糖尿病血管疾病的风险增加相关。因此,本项研究旨在评估被广泛接受的美国人体育锻炼指南对NAFLD的影响的研究。

 

 

       研究人员使用2007-2016年美国国家健康与营养检查调查对成年人进行了系列横断面分析。NAFLD和晚期纤维化是通过使用各种非侵入性方法定义的。一项PA调查表评估了休闲时间PA,与职业有关的PA,与交通有关的PA和总就座时间作为久坐行为。根据PA指南对PA进行了分类。在24588个人(平均年龄,47.4岁;男性为47.9%)中,休闲时间的PA(每周≥150分钟)可以降低40%的NAFLD几率,而与交通有关的PA则使NAFLD风险降低33% 。同时分析总PA和坐位时间显示坐位时间与NAFLD之间的剂量反应相关性(P<0.001)。患有NAFLD的个体与没有NAFLD的个体对PA指南的依从性较低。相反,在没有NAFLD的人群中,人们注意到其对PA闲暇时间的遵守情况有所改善。另外,无论NAFLD状态如何,总坐时间的趋势都显着增加。

 

       研究最后,作者说道:久坐的行为是NAFLD的独立预测因子。在具有NAFLD的人群中,总体上对PA指南的依从性较低,

 

原始出处:

Donghee Kim. Et al. Inadequate Physical Activity and Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty Liver Disease. Hepatology.2020.

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    2020-11-12 gwc384
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    2020-11-11 Jessica

    每天通勤坐地铁都是站着,来回共两个小时,也弥补了一点久坐带来的伤害。

    0

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1型糖尿病患者NAFLD的患病率很高,并且高度依赖于所用的诊断方法和NAFLD定义。

JCEM:青少年非酒精性脂肪性肝病与成年后的2型糖尿病风险

在正常血糖的青少年中,NAFLD与2型糖尿病的风险增加相关。