Science: 一种新型贴片可实现心肌梗死后的心脏重塑,在大鼠、猪模型中被证实!

2020-04-12 王昭月 生物探索

北卡罗来纳州立大学的研究者们开发了一种“现成的”人工心脏贴片,可以直接将心脏细胞产生的愈合因子传递到心脏病发作的部位,这在大鼠和猪中已被证实有效。

细胞治疗是创伤或梗死后心脏修复的一种有效策略,但由于其所用贴片以活细胞为材料,费时耗资、不易长期储存,且会增加肿瘤形成和心律失常的风险。因此北卡罗来纳州立大学的研究者们开发了一种“现成的”人工心脏贴片,可以直接将心脏细胞产生的愈合因子传递到心脏病发作的部位,这在大鼠和猪中已被证实有效。该结果发表在《Science Translational Medicine》上。

研究者以去细胞化的猪心肌细胞为外基质支架,将含有离体人心脏基质细胞分泌因子的合成心脏基质细胞(synthetic cardiac stromal cells, synCSCs)嵌入基质,从而得到现成的心脏贴片(artificial cardiac patch, artCP),它在长期冷冻保存后仍能保持效力。


非细胞心脏补片的制作原理图 来源于:K. Huang et al.

研究者用artCP治疗心脏病发作大鼠模型,发现三周内大鼠心脏功能改善了50%,损伤部位疤痕也减少了30%。之后,研究者又在猪心脏病发作模型中进行了为期7天的试点研究,发现相比于对照组,猪心脏损伤部的疤痕减少了30%,心脏功能也稳定了,这进一步证实了artCP的安全性和有效性。


synCSCs (红色)嵌在artCP内 来源于:K. Huang et al.

资深作者Ke Cheng指出,该贴片可以冷冻并安全储存至少30天,而且由于不含活细胞,因此不会引发病人的免疫排斥反应,该研究标志着现成的心脏贴片疗法应用于临床心肌修复的第一步。

原始出处:
Ke Huang,et al. An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. Science. 08 Apr 2020:

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    2020-08-14 ms5000001097228849

    期待临床

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1764168, encodeId=97591e64168d6, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Tue Aug 11 15:29:36 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798117, encodeId=c6fb1e981170e, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Fri Jun 12 23:29:36 CST 2020, time=2020-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808956, encodeId=fd0980895667, content=期待临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48055410686, createdName=ms5000001097228849, createdTime=Fri Aug 14 19:47:31 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992551, encodeId=edc219925519a, content=<a href='/topic/show?id=551151693b6' target=_blank style='color:#2F92EE;'>#心脏重塑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51693, encryptionId=551151693b6, topicName=心脏重塑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue Sep 01 08:29:36 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376070, encodeId=d55413e6070f2, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Apr 14 11:29:36 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555311, encodeId=17be1555311d0, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Tue Apr 14 11:29:36 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381669, encodeId=7267381669eb, content=希望能进临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Apr 13 22:33:09 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047790, encodeId=3cf7104e790ac, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 12 23:29:36 CST 2020, time=2020-04-12, status=1, ipAttribution=)]
    2020-04-14 jichang
  6. [GetPortalCommentsPageByObjectIdResponse(id=1764168, encodeId=97591e64168d6, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Tue Aug 11 15:29:36 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798117, encodeId=c6fb1e981170e, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Fri Jun 12 23:29:36 CST 2020, time=2020-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808956, encodeId=fd0980895667, content=期待临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48055410686, createdName=ms5000001097228849, createdTime=Fri Aug 14 19:47:31 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992551, encodeId=edc219925519a, content=<a href='/topic/show?id=551151693b6' target=_blank style='color:#2F92EE;'>#心脏重塑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51693, encryptionId=551151693b6, topicName=心脏重塑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue Sep 01 08:29:36 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376070, encodeId=d55413e6070f2, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Apr 14 11:29:36 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555311, encodeId=17be1555311d0, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Tue Apr 14 11:29:36 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381669, encodeId=7267381669eb, content=希望能进临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Apr 13 22:33:09 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047790, encodeId=3cf7104e790ac, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 12 23:29:36 CST 2020, time=2020-04-12, status=1, ipAttribution=)]
    2020-04-14 muzishouyi
  7. [GetPortalCommentsPageByObjectIdResponse(id=1764168, encodeId=97591e64168d6, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Tue Aug 11 15:29:36 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798117, encodeId=c6fb1e981170e, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Fri Jun 12 23:29:36 CST 2020, time=2020-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808956, encodeId=fd0980895667, content=期待临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48055410686, createdName=ms5000001097228849, createdTime=Fri Aug 14 19:47:31 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992551, encodeId=edc219925519a, content=<a href='/topic/show?id=551151693b6' target=_blank style='color:#2F92EE;'>#心脏重塑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51693, encryptionId=551151693b6, topicName=心脏重塑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue Sep 01 08:29:36 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376070, encodeId=d55413e6070f2, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Apr 14 11:29:36 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555311, encodeId=17be1555311d0, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Tue Apr 14 11:29:36 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381669, encodeId=7267381669eb, content=希望能进临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Apr 13 22:33:09 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047790, encodeId=3cf7104e790ac, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 12 23:29:36 CST 2020, time=2020-04-12, status=1, ipAttribution=)]
    2020-04-13 天地飞扬

    希望能进临床

    0

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    2020-04-12 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0

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