Lancet Haematol:UM171扩增脐血干细胞移植

2019-11-07 MedSci MedSci原创

UM171扩增脐血干细胞移植是可行和安全的

脐血移植的优势在于较低的复发率和慢性移植物抗宿主病(GVHD)风险,但感染、严重的急性GVHD和移植相关死亡率较高。UM 171,一种造血干细胞扩增激动剂,已被证明能扩增脐血干细胞,促进小鼠多系血细胞的重建。近日研究人员探讨UM 171单次扩增脐带血移植治疗血液恶性肿瘤的安全性和可行性。

本次研究为单臂,I-II期安全性研究,分为2个阶段。第1阶段中,患者接受2单位的脐带血移植,其中1单位采用UM 171扩增,1单位不使用。植入后开始2阶段研究,接受了UM171-扩增脐带血患者,接受剂量递增设计,以确定实现植入的最小脐带血单位剂量。所有患者接受骨髓消融调节方案。研究的主要终点为UM171扩增移植的可行性、安全性以及造血重建动力学。

27名患者参与研究,4名患者在第1阶段接受了2单位脐带血。在2阶段中,22名患者接受单次UM171扩增移植。平均随访18个月。UM171-扩增后,实现植入的最小脐带血单位剂量为0.52×10 5 CD34阳性细胞。26名患者成功实现UM171扩增移植(96%)。22名接受单次UM171脐带血移植的患者中,平均实现每μL100个中性粒细胞的时间为9.5天,达到500个的时间为18天,未发生移植物失效,血小板恢复时间为42天。最常见的3级非血液学事件为发热性中性粒细胞减少症和菌血症。1名患者(5%)死于治疗相关弥漫性肺泡出血。

研究发现,UM171扩增脐血干细胞移植是可行和安全的。

原始出处:


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    2020-01-23 howi
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    2020-04-20 zhaojie88
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    2020-02-29 changfy
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    2019-11-10 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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    2019-11-09 fengyi812