Redx Pharma宣布新的肺纤维化候选药物RXC006

2018-11-15 MedSci MedSci原创

专注于癌症和纤维化的药物发现和开发的Redx公司近日宣布,其首个用于治疗纤维化的口服porcupine抑制剂RXC006将作为孤儿药物用于治疗特发性肺纤维化(IPF)。

专注于癌症和纤维化的药物发现和开发的Redx公司近日宣布,其首个用于治疗纤维化的口服porcupine抑制剂RXC006将作为孤儿药物用于治疗特发性肺纤维化(IPF)。IPF是一种严重且危及生命的慢性肺病,预后极差,且治疗选择有限,患者肺间质的广泛纤维化形成而肺组织增厚,造成不可逆转地丧失肺组织氧气交换的能力,最常发生在5070岁的老年人。IPF患者的中位生存期仅为3年,美国的年发病率为6.8-16.3 / 100,000

RXC006是一种通过靶向porcupineWnt途径的组分酶)来治疗这种使人衰弱和进行性疾病的新方法。强有力的科学证据表明,该途径与肺部瘢痕形成过程(纤维化)密切相关,这是IPF的标志。随着时间的推移,纤维化导致肺部无法有效发挥作用,最终导致患者窒息死亡。Porcupine抑制剂能够抑制所有Wnt配体的释放,因此能够消除IPF中纤维化的主要驱动因素。临床前测试表明,RXC006在肺部以及肝脏和肾脏中抑制Wnt通路,因此非常有效。


原始出处:

http://www.firstwordpharma.com/node/1604627#axzz5WvWo4v35

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    2019-05-21 jj000001
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    2019-06-16 jianjun66

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