Heart:半乳凝素-3可预测先心病患者的心血管不良事件风险

2018-02-26 MedSci MedSci原创

半乳凝素-3是心衰患者危险分层的生物标志物,本研究的目的旨在评估半乳凝素-3与成年先心病(ACHD)患者发生心血管疾病风险的相关性。本研究纳入了2011年-2013年602名ACHD患者,并对其血浆半乳凝素-3水平进行了检测,主要终点事件是全因死亡率、心衰、住院率、心律失常、血栓栓塞事件和心脏介入治疗。最终,共检测了591名(98%)患者的半乳凝素-3水平,平均年龄33岁,男性占58%,纽约心功能

半乳凝素-3是心衰患者危险分层的生物标志物,本研究的目的旨在评估半乳凝素-3与成年先心病(ACHD)患者发生心血管疾病风险的相关性。

本研究纳入了2011年-2013年602名ACHD患者,并对其血浆半乳凝素-3水平进行了检测,主要终点事件是全因死亡率、心衰、住院率、心律失常、血栓栓塞事件和心脏介入治疗。最终,共检测了591名(98%)患者的半乳凝素-3水平,平均年龄33岁,男性占58%,纽约心功能分级(NYHA)为一级。半乳凝素-3的平均水平为12.7 ng/mL,在7%的患者中水平有所升高。分析结果发现,半乳凝素-3与患者的年龄、心脏药物的使用、NYHA分级、窦性心律失调、心功能不全和N末端B型利钠肽(NT-proBNP)呈正相关性,经过平均4.4年时间的随访,195名(33%)患者出现了主要终点事件,在单变量分析中,半乳凝素-3水平与主要终点事件的发生呈明显相关。

研究结果显示,半乳凝素-3与成年先心病患者的功能容量、心功能和心血管不良事件的发生呈明显相关。

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    2018-02-28 ssnine
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    2018-02-28 zhaojie88
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    2018-02-28 slcumt
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    2018-02-26 131****1460

    学习了受益匪浅

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