JCC: 肌肉减少症是溃疡性结肠炎患者需要抢救治疗的预测因子

2018-10-02 MedSci MedSci原创

溃疡性结肠炎患者中有近四分之一的患者深受急性重症溃疡性结肠炎[ASUC]的影响,因此我们需要一些临床指标来预测何种患者会患有ASUC。肌肉减少症和内脏肥胖可预测克罗恩病的自然病史,但这些代谢因素对ASUC结局的作用尚不清楚。本研究的目的是确定肌肉减少症和内脏肥胖对ASUC结局的影响。

背景及目标
溃疡性结肠炎患者中有近四分之一的患者深受急性重症溃疡性结肠炎[ASUC]的影响,因此我们需要一些临床指标来预测何种患者会患有ASUC。肌肉减少症和内脏肥胖可预测克罗恩病的自然病史,但这些代谢因素对ASUC结局的作用尚不清楚。本研究的目的是确定肌肉减少症和内脏肥胖对ASUC结局的影响。

方法
研究人员调查了住院期间接受腹部CT扫描的ASUC住院患者。由放射学家进行骨骼肌质量和内脏肥胖的量化计算。肌肉减少症被定义为男性的骨骼肌指数<55 cm2/ m2,女性的<39 cm2/ m2。主要观察结果是需要手术治疗。

结果
本项研究共包括了89名ASUC患者,其中39 [43.8%]患者需要医疗救助治疗或手术。三分之二的患者[70%]符合肌肉减少症的定义。相较于没有肌肉减少症的患者,较大比例的肌肉减少症患者需要挽救治疗(56%vs 28%,[OR] 3.98,95%[CI] 1.12-14.1)。内脏[p= 0.23]和皮下脂肪[p= 0.53]均不是预测需要挽救治疗的因素。

结论
腹部CT确定的肌肉减少症是住院UC患者需要进行抢救治疗的新型预测因子。

原始出处:

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    2019-05-04 nymo
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    2018-10-06 121832a9m88暂无昵称

    学习了

    0

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    2018-10-04 lfyang

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