JCC:回肠CD患者疾病活动期的粪便钙卫蛋白和磁共振成像之间的关系

2019-04-06 不详 MedSci原创

磁共振肠造影[MRE]是评估克罗恩病回肠炎症的有效手段[CD]。本研究的目的是通过一个独特的回肠队列中的简单评分将粪便钙卫蛋白[FC]与MRE相关联,并进行长期随访,以判断粪便钙卫蛋白和磁共振成像之间关系及与手术或生物治疗之间的关联。

背景和目的
磁共振肠造影[MRE]是评估克罗恩病回肠炎症的有效手段[CD]。本研究的目的是通过一个独特的回肠队列中的简单评分将粪便钙卫蛋白[FC]与MRE相关联,并进行长期随访,以判断粪便钙卫蛋白和磁共振成像之间关系及与手术或生物治疗之间的关联。

方法
研究人员调取了爱丁堡医疗中心共18138名行MRE及FC检测的CD患者资料。两名肠道放射科医师独立地重新阅读MRE结果,以便通过评估最坏的肠段加上总疾病范围来产生简单的MRE评分[范围0-10]。

结果
研究人员共分析了104例回肠CD患者[L1或L3进行全切除术]评估了119次MRE扫描。受试者工作特征分析显示FC 曲线下面积为0.77 [0.67-0.87,p <0.0001],MRE评分> 1,对于MRE严重炎症的最佳临界值为145μg / g,为69.3%[57.6] -79.5]灵敏度和71.4%[53.7-85.4]特异性,发现FC≥145μg/ g与MRE后3年生物学存活率降低相关,而MRE评分在随访期间,与手术和生物学生存率降低有关。

结论
FC与回肠CD的MRE评估以及与无手术缓解相关。

原始出处:

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    2019-04-08 Homburg
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    2019-04-08 Tamikia