Hypertension:孕产妇糖尿病是儿童高血压的危险因素

2018-12-05 xing.T MedSci原创

由此可见,该研究结果进一步证明母亲糖尿病与儿童晚期的高血压相关,表明儿童体重在这种关联中发挥重要作用。

胎儿宫内状况可能会导致终身血管疾病。母亲糖尿病儿童血管疾病的影响尚未确定。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究的目的是探讨母亲糖尿病与子代10岁前血压(BP)之间的关系。

该研究是一个前瞻性出生队列,其中招募了8301对母亲-子女配对,包括586名(7.1%)糖尿病母亲的孩子。研究人员使用线性回归模拟母亲糖尿病与4岁、7岁和10岁血压之间的关联。建立混合效应模型以评估BP随时间变化的差异。路径分析用于量化潜在介导因素的影响。

母亲糖尿病与10岁时子女的血压升高有关(收缩压:β为1.48; 95%CI为0.36-2.59;舒张期:β为0.86; 95%CI为0.05-1.71)。这种关联与母亲围产期特征无关,它由儿童的体重指数和胎龄、出生类型和出生体重(间接效应比例为73%)所介导。在4岁和7岁时未发现BP的显著差异。纵向分析显示母亲糖尿病组子女的收缩压增加(β为1.16; 95%CI为0.03-2.28)。这些发现在男性中特别相关,表明BP产前编程机制存在性别差异。

由此可见,该研究结果进一步证明母亲糖尿病与儿童晚期的高血压相关,表明儿童体重在这种关联中发挥重要作用。

原始出处:

Joana Oliveira Miranda,et al.Maternal Diabetes Mellitus as a Risk Factor for High Blood Pressure in Late Childhood A Prospective Birth Cohort Study.Hypertension.2018. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11761

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    2019-05-04 feather89
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    2018-12-05 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-12-05 龙胆草

    学习谢谢分享

    0

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