Ophthalmic Plast Reconstr Surg:人体眼眶的胚胎学和发育综述

2018-08-27 MedSci MedSci原创

埃及开罗艾因夏姆斯大学眼科的Tawfik HA和北卡罗来纳大学医学院眼科的Dutton JJ等近日在Ophthalmic Plast Reconstr Surg杂志上发表了一篇文章,他们回顾了最近关于眼眶研究进展的数据,对从胚胎生命早期阶段到胎儿晚期成熟过程中出现的争议等进行了讨论,并对眼眶中特定结构的形态发生进行综述。

埃及开罗艾因夏姆斯大学眼科的Tawfik HA和北卡罗来纳大学医学院眼科的Dutton JJ等近日在Ophthalmic Plast Reconstr Surg杂志上发表了一篇文章,他们回顾了最近关于眼眶研究进展的数据,对从胚胎生命早期阶段到胎儿晚期成熟过程中出现的争议等进行了讨论,并对眼眶中特定结构的形态发生进行综述。

作者广泛回顾了主要的研究,详细总结了人类胚胎在胎儿眼眶形态发生时眼外肌、眼眶脂肪、血管、神经和支持性结缔组织框架以及骨骼等的发育情况。这些跨学科研究跨越了近一个半世纪,其中包括一些有争议的相反观点,作者希望这些观点能够得到合理的解释。作者还重点介绍了一些最值得注意的分子生物学研究,涉及调节正常眼眶形态发生的多种相互作用的信号通路。

眼眶形态发生涉及一系列微妙但严格调节的形态发生事件,这些事件只能通过作者使用的时间顺序叙述来解释。触发并诱导形成眼眶的过程是复杂的,通过多方面相互作用和多种细胞的组织结构(包括发育中的视泡囊、神经外胚层、颅神经嵴细胞和中胚层)之间的相互信息传递来错综复杂地调节其形成。

因此,作者认为,眼眶的发育是一个复杂的系统过程,需要眼眶内外不同细胞群之间进行相互作用。对眼眶发生过程的基本了解是完善其遗传基础或与眼眶疾病相关的胚胎学的关键,将有助于人们对眼眶相关疾病的治疗。

原文出处:

Tawfik, H.A. and J.J. Dutton, Embryologic and Fetal Development of the Human Orbit. Ophthalmic Plast Reconstr Surg, 2018.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 

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    2019-07-27 drj2003
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    2018-08-29 ailian1202
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    2018-08-29 neurowu
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    2018-08-28 131****1460

    学习了受益匪浅

    0

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