Oncotarget:血清外泌体miR-665可能是一种新的肝癌微创诊断和预后生物标志物

2017-12-14 Johnny “外泌体之家”微信号

南京大学医学院鼓楼医院丁义涛教授研究组的一项研究探讨使用血清外泌体miRNAs作为肝细胞癌(HCC)诊断和预后的新型血清生物标志物的可行性。

最近的研究表明,循环miRNA是各种恶性肿瘤的潜在生物标志物。南京大学医学院鼓楼医院丁义涛教授研究组的一项研究探讨使用血清外泌体miRNAs作为肝细胞癌(HCC)诊断和预后的新型血清生物标志物的可行性。研究结果表明:外周血miR-665水平在HCC患者中显着高于健康对照者(P <0.05),外泌体miR-665水平在肿瘤大于5 cm的肿瘤中、在HCC的晚期临床阶段(III/IV期)显着上调(分别为P = 0.0042,0.0197和0.0276)。外泌体miR-665高表达组(n=17)的存活时间显着短于低表达组(n=13)(P=0.036)。此外,他们还发现HCC细胞来源的外泌体促进肝癌细胞增殖,并在体外和体内上调MAPK/ERK途径中蛋白质的表达水平。本研究表明血清外泌体miR-665可能是一种新的微创肝癌诊断和预后生物标志物。

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    2017-12-31 smallant2002
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    2018-10-28 仁医06
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    2017-12-27 liuweigang

    学习.了解.了解

    0

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    2017-12-21 三生有幸9135

    学习一下谢谢分享

    0

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encodeId=553f26964e51, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Dec 15 17:25:13 CST 2017, time=2017-12-15, status=1, ipAttribution=)]
    2017-12-21 jyzxjiangqin

    血清外泌体的含义.

    0

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    2017-12-16 vera_1203
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    2017-12-15 三生有幸9135

    学习一下谢谢分享

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