JAHA:青少年颈动脉内膜中层厚度进展的预测因素

2021-09-07 MedSci原创 MedSci原创

收缩压、动脉高血压、低密度和非高密度脂蛋白胆固醇以及丙氨酸转氨酶可预测青少年cIMT的进展,尽管危险因素水平主要在既定的参考范围内。

血管疾病取决于危险因素暴露的持续时间和时间进程。先前关于年轻人颈动脉内膜中层厚度(cIMT)进展的危险因素的报告大多仅限于高危或易受某些类型偏倚影响的人群。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在根据一般人群颈动脉的重复超声评估来揭示早期血管病理学的危险因素特征。

研究人员从平均年龄为15.8±0.9岁的普通人群中抽取了956名青少年,并评估了危险因素,其中56.2%为女性。在基线和平均22.5±3.4个月后通过高分辨率超声测量了受试者cIMT。研究人员使用线性混合模型对潜在混杂因素进行多变量调整,并探究基线险因素对cIMT进展的影响。

研究人员发现对于丙氨酸转氨酶(5.5μm;95%CI为1.5–9.5)、收缩压(4.7μm;0.3–9.2)、动脉高血压(9.5μm,0.2–18.7)和非高密度脂蛋白胆固醇(4.5μm;0.7–8.4)和低密度脂蛋白胆固醇(4.3微米;0.5–8.1),可得到与cIMT进展之间显著的相关性。
 
由此可见,收缩压、动脉高血压、低密度和非高密度脂蛋白胆固醇以及丙氨酸转氨酶可预测青少年cIMT的进展,尽管危险因素水平主要在既定的参考范围内。这些结果再次强调了生命早期就开始预防的必要性,这些结果挑战了当前指南建议的对高危青少年的关注重点。

原始出处:

Sophia J. Kiechl.et al.Predictors of Carotid Intima‐Media Thickness Progression in Adolescents—The EVA‐Tyrol Study.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020233

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1708657, encodeId=673b1e0865742, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Mon Jan 17 05:59:27 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843629, encodeId=fbc018436292d, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Apr 16 20:59:27 CST 2022, time=2022-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264373, encodeId=e57e12643e30e, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268626, encodeId=cdac126862652, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457367, encodeId=dd8d145e3672c, content=<a href='/topic/show?id=2f2a1005285e' target=_blank style='color:#2F92EE;'>#颈动脉内膜中层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100528, encryptionId=2f2a1005285e, topicName=颈动脉内膜中层厚度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=385c5894378, createdName=grace5702, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1708657, encodeId=673b1e0865742, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Mon Jan 17 05:59:27 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843629, encodeId=fbc018436292d, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Apr 16 20:59:27 CST 2022, time=2022-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264373, encodeId=e57e12643e30e, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268626, encodeId=cdac126862652, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457367, encodeId=dd8d145e3672c, content=<a href='/topic/show?id=2f2a1005285e' target=_blank style='color:#2F92EE;'>#颈动脉内膜中层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100528, encryptionId=2f2a1005285e, topicName=颈动脉内膜中层厚度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=385c5894378, createdName=grace5702, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1708657, encodeId=673b1e0865742, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Mon Jan 17 05:59:27 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843629, encodeId=fbc018436292d, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Apr 16 20:59:27 CST 2022, time=2022-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264373, encodeId=e57e12643e30e, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268626, encodeId=cdac126862652, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457367, encodeId=dd8d145e3672c, content=<a href='/topic/show?id=2f2a1005285e' target=_blank style='color:#2F92EE;'>#颈动脉内膜中层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100528, encryptionId=2f2a1005285e, topicName=颈动脉内膜中层厚度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=385c5894378, createdName=grace5702, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1708657, encodeId=673b1e0865742, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Mon Jan 17 05:59:27 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843629, encodeId=fbc018436292d, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Apr 16 20:59:27 CST 2022, time=2022-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264373, encodeId=e57e12643e30e, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268626, encodeId=cdac126862652, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457367, encodeId=dd8d145e3672c, content=<a href='/topic/show?id=2f2a1005285e' target=_blank style='color:#2F92EE;'>#颈动脉内膜中层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100528, encryptionId=2f2a1005285e, topicName=颈动脉内膜中层厚度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=385c5894378, createdName=grace5702, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=)]
    2021-09-09 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1708657, encodeId=673b1e0865742, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Mon Jan 17 05:59:27 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843629, encodeId=fbc018436292d, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Apr 16 20:59:27 CST 2022, time=2022-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264373, encodeId=e57e12643e30e, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268626, encodeId=cdac126862652, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457367, encodeId=dd8d145e3672c, content=<a href='/topic/show?id=2f2a1005285e' target=_blank style='color:#2F92EE;'>#颈动脉内膜中层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100528, encryptionId=2f2a1005285e, topicName=颈动脉内膜中层厚度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=385c5894378, createdName=grace5702, createdTime=Thu Sep 09 01:59:27 CST 2021, time=2021-09-09, status=1, ipAttribution=)]

相关资讯

NEJM:mRNA-1273疫苗在12-17岁青少年人群中效果评估

mRNA-1273疫苗在12-17岁青少年人群中是安全的,其诱导免疫应答效果与成年人群相当,可有效预防新冠肺炎

TAG: 年龄影响炎症性肠病患者的疾病特征和治疗选择吗?

年轻患者炎症性肠病(IBD)的发病率,例如克罗恩病(CD)和溃疡性结肠炎(UC),在世界范围内正在增加。多达20%的IBD病例在18岁之前被诊断出。

我国近视患者高达6亿!过度使用智能手机可能是视力杀手

青少年近视率越来越高,高中可能占有80%,形势非常严峻。

NEJM:BNT162b2 Covid-19疫苗在青少年中的安全性、免疫原性和有效性分析

12至15岁青少年接受BNT162b2疫苗具有良好的安全性,比年轻人产生更大的免疫反应,并且对预防Covid-19非常有效。

Schizophrenia Bulletin:自残住院的青少年未来患精神心理疾病风险高

在医院就诊的青少年自残是晚期精神病和双相情感障碍的一个强烈的风险标志。自残入院的年轻人未来患精神病和躁郁症的风险很高。他们是预防严重精神疾病的重要群体。

JAHA:环境空气污染对儿童和青少年血压的影响

短期和长期接触某些环境空气污染物可能会升高儿童和青少年的BP。