Clin Translational Gastroenterology: 维生素D和K的水平与慢性胰腺炎骨病相关

2018-11-11 MedSci MedSci原创

骨病在慢性胰腺炎(CP)患者中很常见,而维生素K对骨代谢至关重要,本项研究的目的是评估CP患者骨质疏松症和骨质减少的患病率,并研究骨病和CP特征与营养参数之间的关系,尤其是维生素D和K水平对于骨病的影响。

背景及目的
骨病在慢性胰腺炎(CP)患者中很常见,而维生素K对骨代谢至关重要,本项研究的目的是评估CP患者骨质疏松症和骨质减少的患病率,并研究骨病和CP特征与营养参数之间的关系,尤其是维生素D和K水平对于骨病的影响。

方法
研究人员收集了慢性胰腺炎患者,并通过双能X射线吸收测定法和粪弹性蛋白酶法评估骨密度。营养评估包括维生素D和维生素K.评估有或无骨病患者之间的差异。使用逻辑回归分析研究变量和骨密度之间的关联。

结果
研究人员共纳入了211名CP患者(男性占67%;平均年龄60岁)。总共有18%的患者有晚期CP,56%患有胰腺外分泌功能不全。维生素D和K缺乏分别为56%和32%。骨质疏松症的诊断率为42%,骨质疏松症的诊断率为22%。在多变量分析中,女性(OR 2.78),年龄和更高的BMI与骨质疏松症的存在相关。在男性患者中,与骨质疏松症相关的唯一因素是维生素K缺乏症(OR 4.23)。

结论
本项研究的数据证实CP患者的骨病发生率很高,并且首次证明了维生素K缺乏是男性患者骨质疏松症的危险因素。

原始出处:

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    2018-12-06 hb2008ye
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    2019-03-17 许安
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