Ann Allergy Asthma Immunol:过敏性鼻炎中抑制白介素35的表达和其诱导的调控T细胞能够促进II型先天性淋巴样细胞反应

2020-08-31 AlexYang MedSci原创

据报道,过敏性鼻炎(AR)中白介素(IL)-35和IL-35诱导的调控T细胞(iTr35)能够抑制TH2响应。然而,其对II型先天性淋巴样细胞(ILC2)的影响仍旧不清楚。

据报道,过敏性鼻炎(AR)中白介素(IL)-35和IL-35诱导的调控T细胞(iTr35)能够抑制TH2响应。然而,其对II型先天性淋巴样细胞(ILC2)的影响仍旧不清楚。

最近,有研究人员鉴定了IL-35对ILC2的影响。研究总共包括了25名AR患者和20名对照。研究发现,与对照相比,AR患者的IL-35表达水平和iTr35比例减少,而ILC2和II型细胞因子水平增加。明显的是,IL-35能够通过调控IL-12Rβ2和gp130来抑制ILC2分化和II型下表因子的产生。IL-35能够通过iTr35促进诱导性共刺激分子的表达,以及通过ILC2诱导共刺激分子配体的表达。另外,IL-35处理AR小鼠模型的鼻ILC2频率和功能降低。

小鼠模型中IL-35抑制ILC2响应

最后,研究人员指出,IL-35能够直接的或者通过iTr35和ILC2的互作来抑制ILC2响应,表明了IL-35可作为AR治疗的潜在靶标。

原始出处:

Wenlong Liu, Qingxiang Zeng, Yanhui Wen et al. Inhibited interleukin 35 expression and interleukin 35-induced regulatory T cells promote type II innate lymphoid cell response in allergic rhinitis. Ann Allergy Asthma Immunol. Aug 2020

 

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time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369518, encodeId=49981369518d1, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Wed Sep 02 12:53:51 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372144, encodeId=fb2713e2144a5, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, 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createdName=ms6000001113694287, createdTime=Tue Sep 01 08:03:40 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881593, encodeId=595f881593eb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Tue Sep 01 07:44:04 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-12-11 skhzy
  5. [GetPortalCommentsPageByObjectIdResponse(id=1712532, encodeId=007f1e12532bc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Oct 13 16:53:51 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066014, encodeId=081d20660146d, content=<a href='/topic/show?id=92bf92003b2' target=_blank style='color:#2F92EE;'>#调控T细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92003, encryptionId=92bf92003b2, topicName=调控T细胞)], attachment=null, authenticateStatus=null, 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time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369518, encodeId=49981369518d1, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Wed Sep 02 12:53:51 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372144, encodeId=fb2713e2144a5, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, 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createdName=ms6000001113694287, createdTime=Tue Sep 01 08:03:40 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881593, encodeId=595f881593eb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Tue Sep 01 07:44:04 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-02 膀胱癌
  6. [GetPortalCommentsPageByObjectIdResponse(id=1712532, encodeId=007f1e12532bc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Oct 13 16:53:51 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066014, encodeId=081d20660146d, content=<a href='/topic/show?id=92bf92003b2' target=_blank style='color:#2F92EE;'>#调控T细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92003, encryptionId=92bf92003b2, topicName=调控T细胞)], attachment=null, authenticateStatus=null, 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time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369518, encodeId=49981369518d1, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Wed Sep 02 12:53:51 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372144, encodeId=fb2713e2144a5, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, 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createdName=ms6000001113694287, createdTime=Tue Sep 01 08:03:40 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881593, encodeId=595f881593eb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Tue Sep 01 07:44:04 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-02 huirong
  7. 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  8. 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    2020-09-01 ms3000000449926787

    学习!

    0

  9. 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    2020-09-01 ms6000001113694287

    学习了

    0

  10. 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    2020-09-01 14818eb4m67暂无昵称

    学习

    0

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