Ann Neurol:Covid-19患者Guillain-Barré综合征的发病率、临床特征、危险因素和结局

2020-12-12 MedSci原创 MedSci原创

SARS-CoV-2可能是另一种引起GBS的病毒。

近日,神经病学领域权威取杂志Annals of Neurology上发表了一篇研究文章,研究人员旨在评估Covid-19患者患Guillain-Barré综合征(GBS)的发病率、临床特征、危险因素和结局。

在Covid-19大流行期间,研究人员从在西班牙61个急诊(ED)就诊的71904名COVID患者中诊断出11例格林-巴利综合征(GBS)患者。

研究人员发现ED患者中GBS的相对频率在COVID患者(0.15‰)中高于非COVID患者(0.02‰)(OR=6.30,95%CI=3.18-12.5),其标准化发生率也是如此(分别为9.44和0.69例/100000,OR=13.5;95%CI=9.87-18.4)。就临床特征而言,COVID伴GBS患者的嗅觉-味觉障碍比非COVID伴GBS(OR=27.59,95%CI=1.296-587)和COVID-non-GBS患者(OR=7.875,95%CI=1.587-39.09)更为频繁。尽管COVID-GBS患者更常接受重症监护,但与对照组相比,死亡率并未增加。

该研究结果表明,SARS-CoV-2可能是另一种引起Guillain-Barré综合征的病毒。

原始出处:

Marcos Fragiel,et al.Incidence, clinical characteristics, risk factors and outcomes of Guillain‐Barré syndrome in patients with Covid‐19.Annals of Neurology.2020.https://onlinelibrary.wiley.com/doi/10.1002/ana.25987

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    2021-08-03 yinhl1978
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    2020-12-12 ms7000001361999289

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