SJA:度洛西汀和地塞米松改善腹腔镜妇科手术术后疼痛:随机临床试验

2018-02-13 符校魁 “罂粟花”微信号

患者的手术体验,受到痛苦管理观念的影响。 度洛西汀(Dulox)和地塞米松(Dex)可用于多模式镇痛以减少阿片类药物的使用和副作用。 Dulox是一种选择性5-羟色胺和去甲肾上腺素再摄取抑制剂,对慢性疼痛有效。 Dex增强术后镇痛并减少术后恶心呕吐(PONV)。

背景与目的

患者的手术体验,受到痛苦管理观念的影响。 度洛西汀(Dulox)和地塞米松(Dex)可用于多模式镇痛以减少阿片类药物的使用和副作用。 Dulox是一种选择性5-羟色胺和去甲肾上腺素再摄取抑制剂,对慢性疼痛有效。 Dex增强术后镇痛并减少术后恶心呕吐(PONV)。

方  法

七十五岁的女性患者,随机分为3组。GI组在15分钟内口服Dulox 60mg和100ml 0.9%氯化钠静脉输注,GII:除了Dex 0.1mg / kg与NS混合,其他与GI组相同。GIII术前2 h接受相同的安慰剂 Dulox胶囊和Dex静脉注射。 术后30 min,1 h,2 h,6 h和12 h评估患者的生命质量、视觉模拟评分(VAS)和镇静评分。 记录总哌替啶需要量,血浆皮质醇,PONV和患者满意度。

结  果

术后止疼时间:GI和GII组相比GIII组明显较长,GII比GI明显较长。术后 30 分钟,  GI and GII与GIII相比,1, 2,  6小时VAS评分、心率、平均动脉压力明显更低,镇静评分更高。在术后12 h,GI和GII与GIII相比,杜冷丁的总需求明显减少。GI and GII与GIII相比,血浆皮质醇明显降低,患者满意度升高。GII相比GI和GIII PONY发生明显减少。

结  论

通过减少镇痛药的使用,改善术后疼痛和PONV,术前2 h口服Dulox 60 mg联合Dex 0.1 mg / kg IVI比口服Dulox 60 mg更有效。

原始出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1992276, encodeId=288e19922e6a3, content=<a href='/topic/show?id=8be5493947a' target=_blank style='color:#2F92EE;'>#度洛西汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49394, encryptionId=8be5493947a, topicName=度洛西汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Mon Aug 13 10:25:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661379, encodeId=318f16613e95a, content=<a href='/topic/show?id=5f119844112' target=_blank style='color:#2F92EE;'>#随机临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98441, encryptionId=5f119844112, topicName=随机临床试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbb125274547, createdName=ms117281293605716, createdTime=Sun Sep 02 14:25:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276410, encodeId=1c1012e6410d1, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417445, encodeId=f192141e445d1, content=<a href='/topic/show?id=000a44809ed' target=_blank style='color:#2F92EE;'>#妇科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44809, encryptionId=000a44809ed, topicName=妇科手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74853278623, createdName=hb2009ye, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1992276, encodeId=288e19922e6a3, content=<a href='/topic/show?id=8be5493947a' target=_blank style='color:#2F92EE;'>#度洛西汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49394, encryptionId=8be5493947a, topicName=度洛西汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Mon Aug 13 10:25:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661379, encodeId=318f16613e95a, content=<a href='/topic/show?id=5f119844112' target=_blank style='color:#2F92EE;'>#随机临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98441, encryptionId=5f119844112, topicName=随机临床试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbb125274547, createdName=ms117281293605716, createdTime=Sun Sep 02 14:25:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276410, encodeId=1c1012e6410d1, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417445, encodeId=f192141e445d1, content=<a href='/topic/show?id=000a44809ed' target=_blank style='color:#2F92EE;'>#妇科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44809, encryptionId=000a44809ed, topicName=妇科手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74853278623, createdName=hb2009ye, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1992276, encodeId=288e19922e6a3, content=<a href='/topic/show?id=8be5493947a' target=_blank style='color:#2F92EE;'>#度洛西汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49394, encryptionId=8be5493947a, topicName=度洛西汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Mon Aug 13 10:25:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661379, encodeId=318f16613e95a, content=<a href='/topic/show?id=5f119844112' target=_blank style='color:#2F92EE;'>#随机临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98441, encryptionId=5f119844112, topicName=随机临床试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbb125274547, createdName=ms117281293605716, createdTime=Sun Sep 02 14:25:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276410, encodeId=1c1012e6410d1, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417445, encodeId=f192141e445d1, content=<a href='/topic/show?id=000a44809ed' target=_blank style='color:#2F92EE;'>#妇科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44809, encryptionId=000a44809ed, topicName=妇科手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74853278623, createdName=hb2009ye, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1992276, encodeId=288e19922e6a3, content=<a href='/topic/show?id=8be5493947a' target=_blank style='color:#2F92EE;'>#度洛西汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49394, encryptionId=8be5493947a, topicName=度洛西汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Mon Aug 13 10:25:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661379, encodeId=318f16613e95a, content=<a href='/topic/show?id=5f119844112' target=_blank style='color:#2F92EE;'>#随机临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98441, encryptionId=5f119844112, topicName=随机临床试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbb125274547, createdName=ms117281293605716, createdTime=Sun Sep 02 14:25:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276410, encodeId=1c1012e6410d1, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417445, encodeId=f192141e445d1, content=<a href='/topic/show?id=000a44809ed' target=_blank style='color:#2F92EE;'>#妇科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44809, encryptionId=000a44809ed, topicName=妇科手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74853278623, createdName=hb2009ye, createdTime=Thu Feb 15 02:25:00 CST 2018, time=2018-02-15, status=1, ipAttribution=)]

相关资讯

Diabetes Care:糖尿病周围神经痛药物疗效无显著差异

       来自英国的一项双盲、随机、平行组研究表明,对于慢性糖尿病周围神经痛(DPNP),普瑞巴林、阿米替林和度洛西汀的镇痛效果没有显著差异。但在次要参数(例如睡眠质量等)方面有显著差异。这可能与DPNP最佳治疗决策休戚相关。研究在2012年9月18日在线发表于《糖尿病护理》(Diabetes Care)杂志。   慢性糖尿病周围神经痛治疗难度大,治疗方案往往不足以控制疼痛;同时

BMJ: 期刊文章和临床试验注册中心报告漏报主要危害数据

为了测定临床试验方案、临床研究报告和主要的公开资源(期刊文章和试验注册)之间的数据在疗效和重大危害方面是否有矛盾的地方,以及临床研究报告本身是否矛盾,采用度洛西汀治疗重度抑郁症的研究作为研究对象。研究者从不同数据来源提取主要疗效分析和主要危害的数据并进行比较。9个随机的度洛西汀安慰剂对照试验(共2878个病人)用于重度抑郁症提交给欧盟药品管理局(EMA)审批。研究者于2011年5月从EMA获得包含

JCO:度洛西汀治疗早期乳腺癌患者芳香化酶抑制剂治疗所致的关节痛效果如何?

大家都知道芳香化酶抑制剂(AI)用于早期乳腺癌的治疗,但由于AI相关的肌肉骨骼症状(AIMSS)而使其应用受到限制。度洛西汀是FDA批准用于治疗多种慢性疼痛性疾病,那么度洛西汀与安慰剂相比治疗AIMSS能否缓解关节疼痛呢?2017年11月14日在JCO上发表的一篇文章则回答了这个问题。

Int J Clin Pract:度洛西汀和普瑞巴林治疗 DPNP 安全性相当

据估计 60%-70% 糖尿病患者均会出现某种形式的神经病变,其中最常见的为糖尿病周围神经痛 (DPNP)。目前 FDA 批准用于治疗 DPNP 的药物包括度洛西汀和普瑞巴林,两种药物均被认为治疗安全有效。此外,临床上也常使用加巴喷丁治疗 DPNP,尽管其仅被批准用于疱疹后神经痛。目前尚缺乏这三种药物安全性方面的对

J Clin Oncol:度洛西汀治疗早期乳腺癌女性AI相关肌肉骨骼症状效果好

2017年发表在《J Clin Oncol》的SWOG S1202:度洛西汀vs安慰剂治疗早期乳腺癌中芳香化酶抑制剂(AI)相关关节痛的随机、多中心、安慰剂对照临床试验表明,度洛西汀治疗早期乳腺癌女性AI相关肌肉骨骼症状(AIMSS)的结果优于安慰剂。