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J immunol：TGF-b信号调节树突状细胞分化

2016-07-20 佚名 生物谷

TGF-b
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树突状细胞（DC）具有不同的亚群，每一亚群的DC在基因表达、组织分布、细胞因子分泌以及呈递抗原的种类方面都有明显的区别。由于所有类型的DC都是从骨髓的DC前体细胞分化而来，因子，IRF、HLH、BATF、ETS、STAT等家族转录因子对DC各亚型的分化具有关键的作用。此外，最近的研究指出，notch、wnt、TGF-b等信号通路参与了DC多样性的形成。TGF-b信号激活依赖于其配体蛋白与膜上的受体

树突状细胞（DC）具有不同的亚群，每一亚群的DC在基因表达、组织分布、细胞因子分泌以及呈递抗原的种类方面都有明显的区别。由于所有类型的DC都是从骨髓的DC前体细胞分化而来，因子，IRF、HLH、BATF、ETS、STAT等家族转录因子对DC各亚型的分化具有关键的作用。此外，最近的研究指出，notch、wnt、TGF-b等信号通路参与了DC多样性的形成。

TGF-b信号激活依赖于其配体蛋白与膜上的受体结合。结合之后能够造成下游R-SMAD蛋白的磷酸哈。磷酸化后的R-SMAD能够与SMAD4蛋白集合并向核内移动。进入核内之后，这一复合体能够调节基因的表达。研究表明，TGF-b能够调节DC的分化，缺失TGF-b的小鼠其上皮Langerhans细胞的发育受到了阻碍。由于TGF-b1/BMP能够引发DC中IRF8基因的表达，而后者能够进一步活化TGF-b，从而对抗原呈递细胞以及T细胞产生影响。
 
为了研究IRF8的表达对于DC的分化究竟有怎样的影响，以及其作用机制如何。来自印度新德里大学的Prafullakumar Tailor课题组进行了深入研究，相关结果发表在最近一期的《Journal of immunology》杂志上。
 
首先，作者对正常的DC以及IRF8缺失突变的DC进行了基因表达谱的检测。通过比较，作者发现IRF8的表达能够引发DC中一类叫做Acvrl1的转录因子的表达。通过比较不同亚型的DC的表达情况，作者发现其中IRF8主要表达于CD8阳性的DC亚群中。
 
进一步，作者发现IRF8的表达能够促进CD8阳性的DC的分化。而IRF8与Acvrl1的共同过表达或者IRF8与BMP的共同过表达能够明显提高CD8阳性DC的水平，这说明IRF8与Acvrl1或者BMP信号之间存在协同作用。
 
最后，作者发现在IRF失活突变的情况下，TGF-b1或者BMP的刺激都不能引发SMAP1/5的磷酸化，这说明IRF8对于介导TBF-B的胞内信号传递具有关键的作用。

原始出处

Rohit Verma, Hemant Jaiswal, Kuldeep Singh Chauhan, Monika Kaushik and Prafullakumar Tailor.Cutting Edge: ACVRL1 Signaling Augments CD8α+ Dendritic Cell Development.J immunol.2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2035840, encodeId=d9222035840d5, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Mon Jan 30 11:25:00 CST 2017, time=2017-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570169, encodeId=bcc315e016991, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Fri Jul 22 05:25:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94006, encodeId=39a594006fc, content=了解了解！, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Jul 21 09:33:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93892, encodeId=ca679389279, content=又一个研究机制出来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 19:22:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93893, encodeId=2a2e93893ad, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 19:22:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93894, encodeId=b5bd9389466, content=值得大家去欣赏, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 19:22:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93895, encodeId=fcaf938954b, content=加油加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 19:22:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2017-01-30 changhe713

    #TGF#

    0

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    2016-07-22 karmond

    #细胞分化#

    0

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    2016-07-21 1dd8c52fm63(暂无匿称)

    了解了解！

    0

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    2016-07-20 doctorJiangchao

    又一个研究机制出来了

    0

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    2016-07-20 doctorJiangchao

    加油

    0

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    2016-07-20 doctorJiangchao

    值得大家去欣赏

    0

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    2016-07-20 doctorJiangchao

    加油加油

    0