BMC Gastroenterology: 血小板与淋巴细胞比例对胃癌总体生存的预后作用

2020-02-16 不详 MedSci原创

本项研究旨在总结先前发表的有关胃癌患者血小板与淋巴细胞比率(PLR)对总体生存(OS)的作用的文献。

背景
本项研究旨在总结先前发表的有关癌患者血小板与淋巴细胞比率(PLR)对总体生存(OS)的作用的文献。

方法
研究人员系统地搜索了PubMed,EmBase和Cochrane库,以找出需要审查的合格研究。使用随机效应模型计算合并风险比(HRs)和95%置信区间(CIs)。进行敏感性和亚组分析,并评估出版偏倚。

结果
这项荟萃分析共纳入28项研究,包括15617例癌患者。汇总结果表明,PLR升高与OS差有关(HR:1.37; 95%CI:1.24-1.51;P <0.001)。使用修整和填充方法调整出版偏倚后,调整后的合并HR为1.19(95%CI:1.08–1.33;P= 0.001)。亚组分析表明,回顾性研究显示PLR升高。

结论
胃癌患者中PLR升高与OS差有关。

原始出处:

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    2020-04-13 许安
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