Circ Res:连接疟疾和高血压的桥梁—升高的血管紧张素II

2016-11-01 xing.T MedSci原创

高水平的血管紧张素Ⅱ和免受疟疾肆虐的保护作用之间存在的因果关系,可以为在非洲和南亚裔的人群中观察到的高血压患病率增加的现象提供了一个可能的解释。此外,这种潜在的因果关系也可能是一种有效地治疗脑型疟疾的独特的方法。

几十年来,研究人员一直认为,高血压和疟疾之间存在因果关系,因为长期暴露于疟疾的人群中高血压的患病率较高。最近在心血管疾病权威杂志《Circulation Research》上发表了一篇文章,该文章认为疟疾是导致这种感染性疾病流行的中、低收入国家高血压发生的一个重要原因。这一假设主要是基于疟疾与以下几点相关:(1)妊娠期高血压疾病,(2)儿童生长迟缓、营养不良,这些与成年血压升高有关,(3)升高的血管紧张素II,也与成人高血压相关。

该研究指出,在疟疾流行的地区可能会促进高血压的发生,但血管紧张素II作为一个主要的血压调节因子,并没有被重点考虑。高水平的血管紧张素II可以发挥保护性作用,减少疟疾患者的发病率和死亡率,为在疟疾流行地区高血压高发提供了一种替代的解释。研究者回顾了已经发表的主要研究血管紧张素II和疟疾之间关系的文献,研究者发现遗传学和功能学的研究均表明,高水平的血管紧张素Ⅱ可以可以发挥保护性效应,通过加强血管内皮细胞屏障的完整性来防止脑型疟疾。研究者还提供了强有力的遗传学、功能学和干预实验证据,表明疟疾是导致高血压的一个原因。

由此可见,高水平的血管紧张素Ⅱ和免受疟疾肆虐的保护作用之间存在的因果关系,可以为在非洲和南亚裔的人群中观察到的高血压患病率增加的现象提供一个可能的解释。此外,这种潜在的因果关系也可能是一种有效地治疗脑型疟疾的独特的方法。

原始出处:

Julio Gallego-Delgado, et al. The High Blood Pressure-Malaria Protection Hypothesis. Circulation Research. 2016;119:1071-1075. http://dx.doi.org/10.1161/CIRCRESAHA.116.309602


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    2017-07-03 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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    2016-11-01 保守主义

    继续学习~

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=218230, encodeId=05ab218230da, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Jul 03 22:11:03 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506857, encodeId=ba43150685edc, content=<a href='/topic/show?id=26cf89e4530' target=_blank style='color:#2F92EE;'>#血管紧张素II#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89745, encryptionId=26cf89e4530, topicName=血管紧张素II)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab559833295, createdName=bbwznl, createdTime=Wed Nov 02 15:07:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589289, encodeId=9b16158928909, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Wed Nov 02 15:07:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152655, encodeId=040a1526552e, content=继续学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0f31631005, createdName=保守主义, createdTime=Tue Nov 01 12:48:23 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152654, encodeId=cde0152654c9, content=有意思~, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0f31631005, createdName=保守主义, createdTime=Tue Nov 01 12:48:08 CST 2016, time=2016-11-01, status=1, ipAttribution=)]
    2016-11-01 保守主义

    有意思~

    0

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