IMMUNITY:清华董晨团队揭示新冠康复患者的体液和细胞免疫反应

2020-05-05 MedSci原创 MedSci原创

世界卫生组织已宣布SARS-CoV-2病毒爆发为世界性大流行病。然而,至今为止,我们对于SARS-CoV-2感染后的免疫反应,特别是适应性免疫反应的了解非常有限。

世界卫生组织已宣布SARS-CoV-2病毒爆发为世界性大流行病。然而,至今为止,我们对于SARS-CoV-2感染后的免疫反应,特别是适应性免疫反应的了解非常有限。

最近,清华大学董晨团队采集了近期被治愈的无病毒出院的COVID-19患者的血液。研究人员在8名新出院患者中检测到SARS-CoV-2特异性的体液免疫和细胞免疫。对另一队列的6名患者出院后2周的随访分析也发现了较高的IgG抗体滴度。

在所有14例患者中,有13例患者在假性感染测试中表现出了血清中和活性。值得注意的是,中和抗体滴度与病毒特异性T细胞数量之间存在着强烈的相关性。

因此,该工作为进一步分析SARS-CoV-2的保护性免疫,了解COVID-19的发病机制,尤其是重症患者的发病机制提供了依据。它还对开发一种有效的SARS-CoV-2感染的疫苗具有重要意义。

 

原始出处:

Ling Ni et al. Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals. IMMUNITY (2020). DOI:https://doi.org/10.1016/j.immuni.2020.04.023

 

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    2020-05-07 医生2397
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    2020-05-05 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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