Neurology:缺血性脑卒中患者取栓术后白质高信号负荷变化

2020-01-06 shaosai MedSci原创

目的:为了验证白质高信号(WMH)负荷对经机械取栓术(MR)治疗的急性缺血性脑卒中(AIS)患者神经功能预后、症状性颅内出血率(sICH)和手术成功率的影响。

目的:为了验证白质高信号(WMH)负荷对经机械取栓术(MR)治疗的急性缺血性脑卒中(AIS)患者神经功能预后、症状性颅内出血率(sICH)和手术成功率的影响。

本研究纳入了因大血管闭塞(LVO)导致AIS并行MT的患者。利用半自动平面测量分割软件计算WMH体积,检验WMH体积与较好预后率、MT近乎完全再通率和sICH率的相关性。

结果为,本研究共纳入了496例患者。总体上,共有434(88%)例患者检出WMH(平均为4.93 ± 7.7)。随着WMH体积增加,临床预后结果越差( [aOR]为1.05 /1-cm3 , 95% CI为 1.01-1.06, p = 0.014)。有57%的WMH体积第一百分位和28%WMH体积第四百分位的患者有较好的预后(p < 0.001)。WMH严重性与sICH率无相关性(aOR 0.99, 95% CI 0.93-1.04, p = 0.66),与手术再通率也无相关性(aOR 0.99, 95% CI 0.96-1.02, p = 0.84)。

本研究表明,合并WMH高负荷且因LVO所致AIS患者中,其MT安全性和效能特征与低WMH负荷的相似,WMH负荷也许对是否行MT并无影响。

原始出处:

Boulouis G, Bricout N, Benhassen W,et al.White matter hyperintensity burden in ischemic stroke patients treated with thrombectomy.Neurology.DOI:10.1212/WNL.0000000000008317

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  5. 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topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Wed Jan 08 09:34:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479072, encodeId=498514e9072d4, content=<a href='/topic/show?id=b97f3800ee0' target=_blank style='color:#2F92EE;'>#取栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38007, encryptionId=b97f3800ee0, topicName=取栓)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99077483919, createdName=1249862am74(暂无昵称), createdTime=Wed Jan 08 09:34:00 CST 2020, time=2020-01-08, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1893250, encodeId=7eab189325050, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Oct 30 00:34:00 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765814, encodeId=bd5d1e6581467, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, 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  7. 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createdTime=Sat Jan 11 07:34:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033447, encodeId=6c5d203344e72, content=<a href='/topic/show?id=800638008ea' target=_blank style='color:#2F92EE;'>#取栓术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38008, encryptionId=800638008ea, topicName=取栓术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Mon Jul 13 04:34:00 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417572, encodeId=7021141e5723c, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Wed Jan 08 09:34:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479072, encodeId=498514e9072d4, content=<a href='/topic/show?id=b97f3800ee0' target=_blank style='color:#2F92EE;'>#取栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38007, encryptionId=b97f3800ee0, topicName=取栓)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99077483919, createdName=1249862am74(暂无昵称), createdTime=Wed Jan 08 09:34:00 CST 2020, time=2020-01-08, status=1, ipAttribution=)]
    2020-01-11 yinhl1978
  8. 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  9. 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研究认为血小板聚集抑制剂而非抗凝药物与反复憩室出血有关,停止抗凝治疗导致中风高危险人群缺血性脑卒中危险增加

缺血性脑卒中患者血压管理全攻略

高血压是引起脑卒中的最重要危险因素,脑卒中具有发病率高、死亡率高和致残率高的特点。不同类型的脑卒中,其治疗方式不同。目前认为预防是最好的措施,其中高血压是导致脑卒中的重要可控危险因素,因此,降压治疗对预防卒中发病和复发尤为重要。在今年举办的第十届中国慢病管理大会上,来自首都医科大学附属北京天坛医院神经病学中心的马锐华教授以“缺血性脑卒中患者的血压管理策略”为主题作了精彩报告。首都医科大学附属北

JAMA:18-49岁中青年人群中风后长期死亡风险研究

中青年中风幸存患者长期死亡风险高于一般人群

Neurology:中青年中风风险研究

研究发现,年轻人中风的发病率呈现上升趋势,特别是35岁以上及女性人群的风险显著增加

JAMA Neurol:小剂量Rivaroxaban 联合阿司匹林与缺血性脑卒中风险

对于全身性动脉粥样硬化患者,小剂量的rivaroxaban联合阿司匹林会导致心脏栓塞性中风和未确定来源的栓塞性中风风险降低