Clin Endocrinol：宁光院士发现ERBB-2过表达是恶性嗜铬细胞瘤/副神经节瘤风险因子

2016-01-15 MedSci MedSci原创

上海交通大学医学院的研究人员证实，ERBB-2过表达是恶性嗜铬细胞瘤/副神经节瘤(pheochromocytoma/paraganglioma，PPGL)的一个风险因子。这一研究发现发布在1月9日的《Clinical Endocrinology》杂志上。宁光院士长期致力于内分泌代谢病临床与科研工作，在内分泌肿瘤及糖尿病的诊治与研究领域取得创新性成果。在Science、JAMA、Nat Genet、

上海交通大学医学院的研究人员证实，ERBB-2过表达是恶性嗜铬细胞瘤/副神经节瘤(pheochromocytoma/paraganglioma，PPGL)的一个风险因子。这一研究发现发布在1月9日的《Clinical Endocrinology》杂志上。

宁光院士长期致力于内分泌代谢病临床与科研工作，在内分泌肿瘤及糖尿病的诊治与研究领域取得创新性成果。在Science、JAMA、Nat Genet、Nat Cell Biol、J Am Coll Cardiol等SCI收录杂志发表论文200多篇。

嗜铬细胞瘤(PCC) 来源于肾上腺髓质嗜铬细胞，分泌产生儿茶酚胺：即肾上腺素、去甲肾上腺素和多巴胺，极少数肿瘤为静寂型；副神经节瘤(PGL)起源于肾上腺外嗜铬细胞，位于胸、腹和盆腔脊柱旁交感神经链；二者总称PPGL。

PPGL在交感神经系统肿瘤中约占7%，年发病率0.3/1 000 000。20～50岁多发，女多于男。大多数PPGL为良性，约有12%PPGL为恶性。当前没有很好的组织性或分子标记物来鉴别良性及恶性PPGLs。在以往的横断面研究中，宁光课题组观察发现ERBB-2过表达与恶性PPGLs有关联。新研究旨在在大群体中评估出ERBB-2过表达对PPGLs转移的预测价值。

研究人员对自己的机构中2002-2012年确诊的总共262名PPGLs患者进行了研究。他们采用免疫组化(IHC)分析了原发PPGL肿瘤中ERBB-2蛋白的表达，并通过荧光原位杂交(FISH)检测了ERBB-2扩增。直接Sanger测序检测了ERBB-2 20号外显子突变。在随访期间记录了恶性PPGLs的发生。并采用Kaplan-Meier分析和Cox比例风险模型评估了ERBB-2过表达与PPGLs转移之间的关联。

结果显示，26名(9.9%)患者原发PPGL肿瘤中有ERBB-2过表达，其与ERBB-2扩增显著相关。未发现任何ERBB-2突变。在进行平均4.5年的随访后，总共记录了23例恶性PPGLs，包括8名(30.8%)患者在ERBB-2过表达组，15名(6.4%)患者在ERBB-2阴性组。ERBB-2过表达组和ERBB-2阴性组之间转移发生率分别为5.3例/100人每年和1.4例/100人。Kaplan-Meier分析显示ERBB-2过表达与无转移生存期缩短有关。在调整原发肿瘤的大小和定位后，Cox回归分揭示ERBB-2过表达与恶性PPGLs风险独立相关。

新研究证实，肿瘤中ERBB-2过表达的患者有着更高的风险形成恶性PPGLs。

原始出处：

Wang W, Zhong X, Ye L, Qi Y, Su T, Wei Q, Xie J, Jiang L, Jiang Y, Zhou W, Cui B, Ning G.ERBB-2 overexpression as a risk factor for malignant phaeochromocytomas and paraganglinomas. Clin Endocrinol (Oxf). 2016 Jan 9. doi: 10.1111/cen.13019

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2016-01-26 lq1767

#过表达#

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2016-02-09 zhmscau

#宁光#

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2016-04-23 小华子

#宁光院士#

58 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61459, encodeId=678e6145996, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61460, encodeId=690c61460d3, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, 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createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-29 circlegirl

很有意义

161 0
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createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-29 circlegirl

希望深入学习

105 0
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createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-27 doctording1

不错，赞一个

134 0
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createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-27 doctording1

这篇文章有一定深度

103 0
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createdName=zhmscau, createdTime=Tue Feb 09 08:11:00 CST 2016, time=2016-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006243, encodeId=1b19200624311, content=<a href='/topic/show?id=19764565e19' target=_blank style='color:#2F92EE;'>#宁光院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45657, encryptionId=19764565e19, topicName=宁光院士)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Sat Apr 23 06:11:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61931, encodeId=0dee6193147, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/1f886e5d12c4637fe453ab919f018749/cb630129a57260ee2ad4a625e102da72.jpg, createdBy=c1d01679078, createdName=circlegirl, createdTime=Fri Jan 29 00:30:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61930, encodeId=4a57619307a, content=希望深入学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/1f886e5d12c4637fe453ab919f018749/cb630129a57260ee2ad4a625e102da72.jpg, createdBy=c1d01679078, createdName=circlegirl, createdTime=Fri Jan 29 00:27:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61458, encodeId=2fb46145881, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61459, encodeId=678e6145996, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61460, encodeId=690c61460d3, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61461, encodeId=9f0161461b1, content=值得临床关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475795, encodeId=42a614e579512, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-27 doctording1

是一篇不错的文章

110 0
[GetPortalCommentsPageByObjectIdResponse(id=1958156, encodeId=884a1958156ed, content=<a href='/topic/show?id=48a294126c0' target=_blank style='color:#2F92EE;'>#过表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94126, encryptionId=48a294126c0, topicName=过表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Tue Jan 26 21:11:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649151, encodeId=2bc516491510b, content=<a href='/topic/show?id=2468456550a' target=_blank style='color:#2F92EE;'>#宁光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45655, encryptionId=2468456550a, topicName=宁光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb4f23763610, createdName=zhmscau, createdTime=Tue Feb 09 08:11:00 CST 2016, time=2016-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006243, encodeId=1b19200624311, content=<a href='/topic/show?id=19764565e19' target=_blank style='color:#2F92EE;'>#宁光院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45657, encryptionId=19764565e19, topicName=宁光院士)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Sat Apr 23 06:11:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61931, encodeId=0dee6193147, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/1f886e5d12c4637fe453ab919f018749/cb630129a57260ee2ad4a625e102da72.jpg, createdBy=c1d01679078, createdName=circlegirl, createdTime=Fri Jan 29 00:30:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61930, encodeId=4a57619307a, content=希望深入学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/1f886e5d12c4637fe453ab919f018749/cb630129a57260ee2ad4a625e102da72.jpg, createdBy=c1d01679078, createdName=circlegirl, createdTime=Fri Jan 29 00:27:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61458, encodeId=2fb46145881, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61459, encodeId=678e6145996, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61460, encodeId=690c61460d3, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61461, encodeId=9f0161461b1, content=值得临床关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475795, encodeId=42a614e579512, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-27 doctording1

值得临床关注

90 0
[GetPortalCommentsPageByObjectIdResponse(id=1958156, encodeId=884a1958156ed, content=<a href='/topic/show?id=48a294126c0' target=_blank style='color:#2F92EE;'>#过表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94126, encryptionId=48a294126c0, topicName=过表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Tue Jan 26 21:11:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649151, encodeId=2bc516491510b, content=<a href='/topic/show?id=2468456550a' target=_blank style='color:#2F92EE;'>#宁光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45655, encryptionId=2468456550a, topicName=宁光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb4f23763610, createdName=zhmscau, createdTime=Tue Feb 09 08:11:00 CST 2016, time=2016-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006243, encodeId=1b19200624311, content=<a href='/topic/show?id=19764565e19' target=_blank style='color:#2F92EE;'>#宁光院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45657, encryptionId=19764565e19, topicName=宁光院士)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Sat Apr 23 06:11:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61931, encodeId=0dee6193147, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/1f886e5d12c4637fe453ab919f018749/cb630129a57260ee2ad4a625e102da72.jpg, createdBy=c1d01679078, createdName=circlegirl, createdTime=Fri Jan 29 00:30:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61930, encodeId=4a57619307a, content=希望深入学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/1f886e5d12c4637fe453ab919f018749/cb630129a57260ee2ad4a625e102da72.jpg, createdBy=c1d01679078, createdName=circlegirl, createdTime=Fri Jan 29 00:27:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61458, encodeId=2fb46145881, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61459, encodeId=678e6145996, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61460, encodeId=690c61460d3, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61461, encodeId=9f0161461b1, content=值得临床关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:15:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475795, encodeId=42a614e579512, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sun Jan 17 14:11:00 CST 2016, time=2016-01-17, status=1, ipAttribution=)]
2016-01-17 spoonycyy

#细胞瘤#

32 0

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